WHY THERE IS NO GENE FOR ALCOHOLISM

被引：13

作者：

DEVOR, EJ

机构：

[1] Department of Psychiatry Administration, University of Iowa Hospitals and Clinics, Iowa City, 52242-1057, Iowa, 200 Hawkins Drive

来源：

BEHAVIOR GENETICS | 1993年 / 23卷 / 02期

关键词：

ALCOHOLISM; HEURISTIC MODEL; LINKAGE STUDIES; ASSOCIATION STUDIES;

D O I：

10.1007/BF01067419

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The search for and recognition of biological and genetic markers of alcoholism are discussed in the context of a heuristic model of human alcoholism as a complex, multilocus, heterogeneous disorder. Implications of this model for the interpretation of results from both linkage and association studies are presented.

引用

页码：145 / 151

页数：7

共 58 条

[1]

ALEXOPOULOS GS, 1981, AM J PSYCHIAT, V138, P1254

[2]

ANOKINA IP, 1989, BIOMED BIOCHIM ACTA, V48, P593

[3] ALLELIC ASSOCIATION OF HUMAN DOPAMINE-D2 RECEPTOR GENE IN ALCOHOLISM [J].

BLUM, K ;

NOBLE, EP ;

SHERIDAN, PJ ;

MONTGOMERY, A ;

RITCHIE, T ;

JAGADEESWARAN, P ;

NOGAMI, H ;

BRIGGS, AH ;

COHN, JB .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 263 (15) :2055-2060

[4] ASSOCIATION OF THE AL ALLELE OF THE D2 DOPAMINE RECEPTOR GENE WITH SEVERE ALCOHOLISM [J].

BLUM, K ;

NOBLE, EP ;

SHERIDAN, PJ ;

FINLEY, O ;

MONTGOMERY, A ;

RITCHIE, T ;

OZKARAGOZ, T ;

FITCH, RJ ;

SADLACK, F ;

SHEFFIELD, D ;

DAHLMANN, T ;

HALBARDIER, S ;

NOGAMI, H .

ALCOHOL, 1991, 8 (05) :409-416

[5]

BOLOS A M, 1990, Journal of the American Medical Association, V264, P3156, DOI 10.1001/jama.264.24.3156

[6]

BOTSTEIN D, 1980, AM J HUM GENET, V32, P314

[7] EFFECTS OF MIS-SPECIFYING GENETIC-PARAMETERS IN LOD SCORE ANALYSIS [J].

CLERGETDARPOUX, F ;

BONAITIPELLIE, C ;

HOCHEZ, J .

BIOMETRICS, 1986, 42 (02) :393-399

[8] NEUROGENETIC ADAPTIVE-MECHANISMS IN ALCOHOLISM [J].

CLONINGER, CR .

SCIENCE, 1987, 236 (4800) :410-416

[9]

CLONINGER CR, 1991, JAMA-J AM MED ASSOC, V266, P1833

[10] THE DOPAMINE-D2 RECEPTOR LOCUS AS A MODIFYING GENE IN NEUROPSYCHIATRIC DISORDERS [J].

COMINGS, DE ;

COMINGS, BG ;

MUHLEMAN, D ;

DIETZ, G ;

SHAHBAHRAMI, B ;

TAST, D ;

KNELL, E ;

KOCSIS, P ;

BAUMGARTEN, R ;

KOVACS, BW ;

LEVY, DL ;

SMITH, M ;

BORISON, RL ;

EVANS, DD ;

KLEIN, DN ;

MACMURRAY, J ;

TOSK, JM ;

SVERD, J ;

GYSIN, R ;

FLANAGAN, SD .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 266 (13) :1793-1800

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