STRONG IMMUNOREACTIVITY OF ALPHA-1-ANTICHYMOTRYPSIN COLOCALIZES WITH BETA-AMYLOID PROTEIN AND UBIQUITIN IN VACUOLATED MUSCLE-FIBERS OF INCLUSION-BODY MYOSITIS

被引：46

作者：

BILAK, M ^{[1
]}

ASKANAS, V ^{[1
]}

ENGEL, WK ^{[1
]}

机构：

[1] UNIV SO CALIF,USC NEUROMUSCULAR CTR,SCH MED,DEPT NEUROL,637 S LUCAS AVE,LOS ANGELES,CA 90017

来源：

ACTA NEUROPATHOLOGICA | 1993年 / 85卷 / 04期

关键词：

ALPHA-1-ANTICHYMOTRYPSIN; BETA-AMYLOID PROTEIN; UBIQUITIN; INCLUSION-BODY MYOSITIS;

D O I：

10.1007/BF00334447

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In 10 of 10 inclusion-body myositis (IBM) patients, including 1 hereditary case, vacuolated muscle fibers contained large or small cytoplasmic inclusions immunoreactive for alpha1-antichymotrypsin (alpha1-ACT). All IBM muscle biopsies had characteristic cytoplasmic tubulo-filaments by electron microscopy. None of 17 control muscle biopsies contained the alpha1-ACT immunoreactive inclusions characteristic of IBM. In vacuolated muscle fibers, alpha1-ACT immunoreactive inclusions colocalized with beta-amyloid protein and ubiquitin immunoreactivities. Our study provides the first demonstration of alpha1-ACT accumulations in abnormal human muscle, and it suggest that, as in Alzheimer's disease and Down's syndrome, alpha1-ACT may be involved in the pathogenesis of IBM.

引用

页码：378 / 382

页数：5

共 36 条

[1] A CALCIUM-ACTIVATED PROTEASE FROM ALZHEIMERS-DISEASE BRAIN CLEAVES AT THE N-TERMINUS OF THE AMYLOID BETA-PROTEIN [J].

ABRAHAM, CR ;

DRISCOLL, J ;

POTTER, H ;

VANNOSTRAND, WE ;

TEMPST, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 174 (02) :790-796

[2] ALPHA-1-ANTICHYMOTRYPSIN IS ASSOCIATED SOLELY WITH AMYLOID DEPOSITS CONTAINING THE BETA-PROTEIN - AMYLOID AND CELL LOCALIZATION OF ALPHA-1-ANTICHYMOTRYPSIN [J].

ABRAHAM, CR ;

SHIRAHAMA, T ;

POTTER, H .

NEUROBIOLOGY OF AGING, 1990, 11 (02) :123-129

[3] IMMUNOCHEMICAL IDENTIFICATION OF THE SERINE PROTEASE INHIBITOR ALPHA-1-ANTICHYMOTRYPSIN IN THE BRAIN AMYLOID DEPOSITS OF ALZHEIMERS-DISEASE [J].

ABRAHAM, CR ;

SELKOE, DJ ;

POTTER, H .

CELL, 1988, 52 (04) :487-501

[4] IMMUNOLOCALIZATION OF UBIQUITIN IN MUSCLE BIOPSIES OF PATIENTS WITH INCLUSION BODY MYOSITIS AND OCULOPHARYNGEAL MUSCULAR-DYSTROPHY [J].

ASKANAS, V ;

SERDAROGLU, P ;

ENGEL, WK ;

ALVAREZ, RB .

NEUROSCIENCE LETTERS, 1991, 130 (01) :73-76

[5] IMMUNOCYTOCHEMICAL LOCALIZATION OF DESMIN AT HUMAN NEUROMUSCULAR-JUNCTIONS [J].

ASKANAS, V ;

BORNEMANN, A ;

ENGEL, WK .

NEUROLOGY, 1990, 40 (06) :949-953

[6]

ASKANAS V, 1992, AM J PATHOL, V141, P31

[7] BETA-AMYLOID PROTEIN IMMUNOREACTIVITY IN MUSCLE OF PATIENTS WITH INCLUSION-BODY MYOSITIS [J].

ASKANAS, V ;

ENGEL, WK ;

ALVAREZ, RB ;

GLENNER, GG .

LANCET, 1992, 339 (8792) :560-561

[8] IMMUNOCYTOCHEMICAL LOCALIZATION OF UBIQUITIN IN INCLUSION BODY MYOSITIS ALLOWS ITS LIGHT-MICROSCOPIC DISTINCTION FROM POLYMYOSITIS [J].

ASKANAS, V ;

SERDAROGLU, P ;

ENGEL, WK ;

ALVAREZ, RB .

NEUROLOGY, 1992, 42 (02) :460-461

[9] INCLUSION BODY MYOSITIS - DISTINCT VARIETY OF IDIOPATHIC INFLAMMATORY MYOPATHY [J].

CARPENTER, S ;

KARPATI, G ;

HELLER, I ;

EISEN, A .

NEUROLOGY, 1978, 28 (01) :8-17

[10]

CARRELL RW, 1987, PROTEINASE INHIBITOR, P403

← 1 2 3 4 →