ORGANIZATION OF A RAINBOW-TROUT ESTROGEN-RECEPTOR GENE

被引：45

作者：

LEROUX, MG ^{[1
]}

THEZE, N ^{[1
]}

WOLFF, J ^{[1
]}

LEPENNEC, JP ^{[1
]}

机构：

[1] UNIV RENNES 1,GENET MOLEC LAB,CNRS,URA 256,CAMPUS BEAULIEU,F-35042 RENNES,FRANCE

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1172卷 / 1-2期

关键词：

ESTROGEN RECEPTOR; STEROID HORMONE RECEPTOR; (RAINBOW TROUT);

D O I：

10.1016/0167-4781(93)90302-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The complete coding region of the estrogen receptor gene was isolated from a rainbow trout genomic library. This gene is divided into ten exons spanning at least 30 kb of genomic DNA. With two exceptions, intron positions are identical to those of the human estrogen receptor gene. The 5' end of the gene, including 1.7 kb of the promoter region, was sequenced. This region exhibits several putative regulatory elements. Localization of a potential estrogen responsive element to the first exon suggests that this gene is autoregulated. This 5' end region was also shown to be able to drive the expression of a CAT reporter gene in Xenopus laevis oocytes.

引用

页码：226 / 230

页数：5

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