CARBON-BASED NUCLEOPHILIC RING-OPENING OF ACTIVATED MONOCYCLIC BETA-LACTAMS - SYNTHESIS AND STEREOCHEMICAL ASSIGNMENT OF THE ACE-INHIBITOR WF-10129

被引：26

作者：

BALDWIN, JE ^{[1
]}

ADLINGTON, RM ^{[1
]}

RUSSELL, AT ^{[1
]}

SMITH, ML ^{[1
]}

机构：

[1] UNIV OXFORD,OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON | 1995年 / 51卷 / 16期

关键词：

D O I：

10.1016/0040-4020(95)00157-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of gamma-keto alpha-amino acids via carbon based nucleophilic ring opening of activated monocyclic beta-lactams was examined and applied to the synthesis and stereochemical assignment of the dipeptide angiotensin converting enzyme (ACE) inhibitor, WF-10129.

引用

页码：4733 / 4762

页数：30

共 31 条

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