EFFECT OF CEFTRIAXONE ON PSEUDOMONAS-AERUGINOSA AND STAPHYLOCOCCUS-AUREUS IN BROTH, SERUM, AND IN COMBINATION WITH HUMAN POLYMORPHONUCLEAR LEUKOCYTES

被引：18

作者：

BASSLER, M ^{[1
]}

BLASCHKE, H ^{[1
]}

JUST, M ^{[1
]}

DASCHNER, FD ^{[1
]}

机构：

[1] UNIV HOSP FREIBURG, DEPT HOSP EPIDEMIOL, D-7800 FREIBURG, GERMANY

来源：

CHEMOTHERAPY | 1982年 / 28卷 / 05期

关键词：

D O I：

10.1159/000238127

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The antibacterial activity of ceftriaxone was investigated at concentrations of 0.25 .times. minimum inhibition concentration (MIC), 1 .times. MIC and 4 .RTM. MIC against a serum-resistant P. aeruginosa and a serum-resistant S. aureus strain in broth, serum and in combination with leukocytes. The killing effect of ceftriaxone in broth was significantly better than in serum; ceftriaxone improved leukocyte bactericidal activity without serum on P. aeruginosa, but not on S. aureus. The antibacterial activity of ceftriaxone was most effective in combination with leukocytes and serum, achieving a marked bactericidal effect already at subinhibitory ceftriaxone concentrations.

引用

页码：390 / 396

页数：7

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