OVARIAN-STEROIDS INCREASE VERATRIDINE-INDUCED RELEASE OF AMINO-ACID NEUROTRANSMITTERS IN PREOPTIC AREA SYNAPTOSOMES

被引：31

作者：

FLEISCHMANN, A

MAKMAN, MH

ETGEN, AM

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,BRONX,NY 10461

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT BIOCHEM,BRONX,NY 10461

[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MOLEC PHARMACOL,BRONX,NY 10461

来源：

BRAIN RESEARCH | 1990年 / 507卷 / 01期

关键词：

Estradiol; Glutamate release; Hypothalamus; Preoptic area; Progesterone; Synaptosome; γ-Aminobutyric acid release;

D O I：

10.1016/0006-8993(90)90538-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In vivo treatment of ovariectomized rats with estradiol benzoate plus progesterone, but not with either steroid alone, produced a large increase in veratridine-induced release of radiolabeled glutamate and newly synthesized GABA from preoptic area synaptosomes in vitro. Neither basal nor KCl-evoked release of amino acids was altered. Thus gonadal steroids appear to be involved in the control of amino acid neurotransmitter release in a brain region of importance for regulation of female reproductive physiology and behavior. © 1990.

引用

页码：161 / 163

页数：3

共 12 条

[1] SEX-DIFFERENCES IN THE EXTRACELLULAR CA-2+-INDEPENDENT RELEASE OF LH AND FSH [J].