CYSTEINE, A CHELATING MOIETY FOR SYNTHESIS OF TC-99M) RADIOPHARMACEUTICALS .3. FUNCTIONALIZATION OF HYDROXY GROUP FOR TC-99M) CHELATION

被引：4

作者：

CHATTERJEE, M ^{[1
]}

BANERJEE, S ^{[1
]}

机构：

[1] INDIAN INST CHEM BIOL,DEPT NUCL MED,4 RAJA SC MULLICK RD,CALCUTTA 700032,W BENGAL,INDIA

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1990年 / 11卷 / 04期

关键词：

D O I：

10.1097/00006231-199004000-00008

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A method is offered for converting an organic hydroxy compound to a99Tcm-binding ligand under mild experimental conditions. Cyclohexanol was selected as a typical hydroxy compound and to this molecule cysteine was attached through substitution at the sulphur atom by a two-step chemical synthesis. The ligand thus obtained could be successfully radiolabelled with99Tcm. The biodistribution of the resulting radiolabelled compound had the characteristic of a mixed hydrophilic-lipophilic99Tcmchelate and was similar to that of99Tcm-H1DA derivatives, a well established class of99Tcm-chelates. So it may be concluded that the above method of functionalization of a hydroxy compound does not generate any unusual physiological properties and may be recommended as a general method for radiolabelling an organic compound at the alcoholic site with99Tcm. © 1990 Chapman and Hall Ltd.

引用

页码：305 / 312

页数：8

共 14 条

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