H-1-NMR OBSERVATION OF TISSUE MYOGLOBIN - AN INDICATOR OF CELLULAR OXYGENATION INVIVO

被引：42

作者：

JUE, T ^{[1
]}

ANDERSON, S ^{[1
]}

机构：

[1] UNIV CALIF DAVIS,DEPT HUMAN PHYSIOL,DAVIS,CA 95616

来源：

MAGNETIC RESONANCE IN MEDICINE | 1990年 / 13卷 / 03期

关键词：

D O I：

10.1002/mrm.1910130322

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Cellular oxygen status is a critical parameter. To measure the oxygen tension in vivo, however, demands extant techniques to surmount two experimental difficulties: invasive experimental protocols and imprecise tissue localization. NMR techniques have the potential to overcome these obstacles. Indeed we show in this study that cellular myoglobin is NMR visible and its proximal histidyl NH signal in the deoxy state can be used to monitor changes in cellular oxygenation. Coupled with recent advances in NMR signal localization, this 1H NMR strategy promises to lead directly to cellular oxygen measurement in specific tissue regions in vivo. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

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页码：524 / 528

页数：5

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