EXPRESSION OF HISTAMINE H1-RECEPTORS IN XENOPUS OOCYTES INJECTED WITH MESSENGER-RIBONUCLEIC-ACID FROM BOVINE ADRENAL-MEDULLA - PERTUSSIS TOXIN INSENSITIVE ACTIVATION OF MEMBRANE CHLORIDE CURRENTS

被引：6

作者：

MEYERHOF, W

SCHWARZ, JR

HOLLT, V

RICHTER, D

机构：

[1] UNIV HAMBURG,KRANKENHAUS EPPENDORF,INST ZELLBIOCHEM & KLIN NEUROBIOL,MARTINISTR 52,W-2000 HAMBURG 20,GERMANY

[2] UNIV HAMBURG,KRANKENHAUS EPPENDORF,INST PHYSIOL,W-2000 HAMBURG 20,GERMANY

[3] UNIV MUNICH,INST PHYSIOL,W-8000 MUNICH 2,GERMANY

来源：

JOURNAL OF NEUROENDOCRINOLOGY | 1990年 / 2卷 / 04期

关键词：

adrenal gland; chloride channels; histamine H[!sub]1[!/sub]receptors; pertussis toxin; Xenopus oocytes;

D O I：

10.1111/j.1365-2826.1990.tb00446.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Histamine H2‐receptors have been identified in Xenopus oocytes previously microinjected with poly(A) + ribonucleic acid from bovine adrenal glands. Bath application of histamine to ribonucleic acid‐primed oocytes evoked concentration‐dependent, oscillating membrane currents under voltage‐clamp conditions. H1‐receptor specific antagonists clemastine, doxepin, pyrilamine, promethacine, diphenylhydramine, dephenylpyraline and chlorpheniramine, but not H2‐receptor antagonists, cimetidine and ranitidine, inhibited histamine‐induced responses. Membrane currents evoked by bath‐applied histamine were insensitive to pertussis toxin, carried by chloride ions and dependent on intracellular but not extracellular calcium. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：547 / 553

页数：7

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