The dynamic interplay among lipids has been exploited by S. mansoni to evolve some unique processes that are vital for its long-term survival within the mammalian host. Lipids are required by the parasite not only to maintain its surface integrity and structural requirements but also for egg production and cell-cell signalling. However, S. mansoni is incapable of synthesizing essential lipids and must obtain these from its host. In this review, Stephen Furlong describes the roles and routes of acquisition of lipids by this parasite.