RAF-1 IS A POTENTIAL SUBSTRATE FOR MITOGEN-ACTIVATED PROTEIN-KINASE INVIVO

被引：128

作者：

ANDERSON, NG

PING, LI

MARSDEN, LA

WILLIAMS, N

ROBERTS, TM

STURGILL, TW

机构：

[1] UNIV VIRGINIA,DEPT PHARMACOL,CHARLOTTESVILLE,VA 22908

[2] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115

[3] UNIV VIRGINIA,DEPT INTERNAL MED,CHARLOTTESVILLE,VA 22908

来源：

BIOCHEMICAL JOURNAL | 1991年 / 277卷

关键词：

D O I：

10.1042/bj2770573

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MAP (mitogen-activated protein) kinase is shown to phosphorylate baculovirally expressed Raf-1 in vitro, generating one major tryptic phosphopeptide which co-migrated with a peptide from Raf-1 P-32-labelled in situ. This peptide also undergoes an insulin-dependent increase in labelling. Thus the serine/threonine kinase Raf-1 may be a substrate for MAP kinase in vivo.

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页码：573 / 576

页数：4

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