LEUKEMIA INHIBITORY FACTOR RECEPTOR IS STRUCTURALLY RELATED TO THE IL-6 SIGNAL TRANSDUCER, GP130

被引：576

作者：

GEARING, DP

THUT, CJ

VANDENBOS, T

GIMPEL, SD

DELANEY, PB

KING, J

PRICE, V

COSMAN, D

BECKMANN, MP

机构：

[1] Immunex Corporation, Seattle, WA 98101

来源：

EMBO JOURNAL | 1991年 / 10卷 / 10期

关键词：

CDNA CLONING; HEMATOPOIETIN RECEPTOR; IL-6; LIF; PLACENTA;

D O I：

10.1002/j.1460-2075.1991.tb07833.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin-6 (IL-6) although LIF and IL-6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 'signal-transducing' component of the IL-6 receptor and to the G-CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross-hybridization and share 70% amino acid sequence identity to the human sequence.

引用

页码：2839 / 2848

页数：10

共 70 条

[1] DIFFERENTIATION-INDUCING FACTOR PURIFIED FROM CONDITIONED MEDIUM OF MITOGEN-TREATED SPLEEN-CELL CULTURES STIMULATES BONE-RESORPTION [J].