MANY-TRILLIONFOLD AMPLIFICATION OF SINGLE RNA VIRUS-PARTICLES FAILS TO OVERCOME THE MULLER RATCHET EFFECT

被引:52
作者
DUARTE, EA
CLARKE, DK
MOYA, A
ELENA, SF
DOMINGO, E
HOLLAND, J
机构
[1] UNIV CALIF SAN DIEGO, DEPT BIOL, 9500 GILMAN DR, LA JOLLA, CA 92093 USA
[2] UNIV CALIF SAN DIEGO, CTR MOLEC GENET, LA JOLLA, CA 92093 USA
[3] UNIV VALENCIA, FAC BIOL, DEPT GENET, VALENCIA, SPAIN
[4] UNIV VALENCIA, FAC BIOL, SERV BIOINFORMAT, VALENCIA, SPAIN
[5] UNIV AUTONOMA MADRID, CSIC, CTR BIOL MOLEC SEVERO OCHOA, E-28049 MADRID, SPAIN
关键词
D O I
10.1128/JVI.67.6.3620-3623.1993
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We showed earlier that transfers of large populations of RNA viruses lead to fitness gains and that repeated genetic bottleneck transfers result in fitness losses due to Muller's ratchet. In the present study, we examined the effects of genetic bottleneck passages intervening between population passages, a process akin to some natural viral transmissions, using vesicular stomatitis virus as a model. Our findings show that the pronounced fitness increases that occur during two successive population passages cannot overcome the fitness decreases caused by a single intervening genetic bottleneck passage. The implications for natural transmissions of RNA viruses are discussed.
引用
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页码:3620 / 3623
页数:4
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