VALPROIC ACID IN THE PERINATAL-PERIOD - DECREASED MATERNAL SERUM-PROTEIN BINDING RESULTS IN FETAL ACCUMULATION AND NEONATAL DISPLACEMENT OF THE DRUG AND SOME METABOLITES

被引:99
作者
NAU, H [1 ]
HELGE, H [1 ]
LUCK, W [1 ]
机构
[1] FREE UNIV BERLIN, DEPT PEDIAT, D-1000 BERLIN 33, FED REP GER
关键词
D O I
10.1016/S0022-3476(84)80567-3
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
引用
收藏
页码:627 / 634
页数:8
相关论文
共 31 条
[1]   FREE FRACTION OF VALPROIC ACID - INVITRO TIME-DEPENDENT INCREASE AND CORRELATION WITH FREE FATTY-ACID CONCENTRATION IN HUMAN-PLASMA AND SERUM [J].
ALBANI, F ;
RIVA, R ;
PROCACCIANTI, G ;
BARUZZI, A ;
PERUCCA, E .
EPILEPSIA, 1983, 24 (01) :65-73
[2]  
BJERKEDAL T, 1982, LANCET, V2, P1096
[3]  
BURT RL, 1960, OBSTET GYNECOL, V15, P460
[4]   CONCENTRATIONS OF FREE FATTY-ACIDS IN MATERNAL AND UMBILICAL-CORD BLOOD DURING ELECTIVE CESAREAN-SECTION [J].
ELPHICK, MC ;
HULL, D ;
SANDERS, RR .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1976, 83 (07) :539-544
[5]  
HAMAR C, 1980, PEDIATR PHARMACOL, V1, P31
[6]   SERUM-PROTEIN BINDING OF DRUGS AND BILIRUBIN IN NEWBORN-INFANTS AND THEIR MOTHERS [J].
HAMAR, C ;
LEVY, G .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1980, 28 (01) :58-63
[7]   DRUG-THERAPY - BINDING OF DRUGS TO SERUM-ALBUMIN .1. [J].
KOCHWESER, J ;
SELLERS, EM .
NEW ENGLAND JOURNAL OF MEDICINE, 1976, 294 (06) :311-316
[8]   DIFFERENCES IN INVITRO BINDING OF DIAZEPAM AND N-DESMETHYLDIAZEPAM TO MATERNAL AND FETAL PLASMA-PROTEINS AT BIRTH - RELATION TO FREE FATTY-ACID CONCENTRATION AND OTHER PARAMETERS [J].
KUHNZ, W ;
NAU, H .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1983, 34 (02) :220-226
[9]  
LEVY G, 1975, CLIN PHARMACOL THER, V18, P210
[10]   MONITORING OF FREE VALPROIC ACID LEVELS [J].
LEVY, RH .
THERAPEUTIC DRUG MONITORING, 1980, 2 (02) :199-201