CHIRALITY OF THE SULFOXIDE METABOLITES OF FENBENDAZOLE AND ALBENDAZOLE IN SHEEP

被引：58

作者：

DELATOUR, P ^{[1
]}

BENOIT, E ^{[1
]}

GARNIER, F ^{[1
]}

BESSE, S ^{[1
]}

机构：

[1] NATL SCH VET MED LYON,DEPT BIOCHEM,LYONS,FRANCE

来源：

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS | 1990年 / 13卷 / 04期

关键词：

D O I：

10.1111/j.1365-2885.1990.tb00790.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Delatour, P., Benoit, E., Gamier, F. & Besse, S. Chirality of the sulphoxide metabolites of fenbendazole and albendazole in sheep. J. vet. Pharmacol. Therap. 13, 361–366. Two prochiral sulphide drugs, fenbendazole (FBZ) and albendazole (ABZ) were administered orally to sheep. Blood samples were analysed for parent drug and S‐oxidation metabolites and the chirality of the sulphoxide metabolites was determined. The plasma concentrations of the enantiomers of the sulphoxides were never a racemate. On the contrary, the ratios were greater than 1 as soon as the sulphoxide compounds could be detected in plasma. They subsequently increased linearly throughout the time course of the kinetics, reaching the level 86:14 after FBZ and 95:5 after ABZ treatment. The major enantiomer represented 74% and 86% of the total AUC of SO FBZ and SO ABZ, respectively. P. Delatour, Department of Biochemistry, National School of Veterinary Medicine of Lyon, BP 83, 69280‐Marcy I'Etoile, France. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：361 / 366

页数：6

共 22 条

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