ACUTE DYSTONIC REACTION IN NORMAL HUMANS CAUSED BY CATECHOLAMINE DEPLETION

被引：22

作者：

MCCANN, UD

PENETAR, DM

BELENKY, G

机构：

[1] Dept. of Behavioral Biology, WRAIR, Washington

来源：

CLINICAL NEUROPHARMACOLOGY | 1990年 / 13卷 / 06期

关键词：

Acetylcholine; Dopamine; Dystonia; α-Methyl-para-tyrosine (AMPT);

D O I：

10.1097/00002826-199012000-00009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Five of 24 (21%) normal men (volunteers) administered α-methyl-para-tyrosine (AMPT), a catecholamine-depleting agent, developed acute dystonic reactions. The finding that catecholamine depletion without receptor blockade is sufficient to cause acute dystonia suggests that a variety of neurotransmitter imbalances may lead to idiopathic primary dystonia.

引用

页码：565 / 568

页数：4

共 12 条

[1]

ARANA GW, 1988, AM J PSYCHIAT, V145, P993

[2] TETRABENAZINE INDUCES ACUTE DYSTONIC REACTIONS [J].