EFFECTS OF REPEATED DOPAMINE-D(1) RECEPTOR STIMULATION ON ROTATION AND C-FOS EXPRESSION

被引：55

作者：

ASIN, KE ^{[1
]}

WIRTSHAFTER, D ^{[1
]}

机构：

[1] UNIV ILLINOIS,DEPT PSYCHOL,CHICAGO,IL 60680

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 235卷 / 01期

关键词：

DOPAMINE-D(1) RECEPTOR; C-FOS; TOLERANCE;

D O I：

10.1016/0014-2999(93)90840-E

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acute injections of the full dopamine D1 receptor agonist A-77636 ((1R,3S)-3-(1'adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride) induce ipsilateral Fos-like immunoreactivity and contralateral rotation into rats bearing unilateral dopamine depleting lesions. However, following repeated treatment, A-77636 fails to induce either striatal c-fos or rotation. Our results suggest that striatal c-fos activation mirrors behavioral indices of dopamine D1 receptor sensitivity.

引用

页码：167 / 168

页数：2

共 6 条

[1] RAPID REVERSAL OF DENERVATION SUPERSENSITIVITY OF DOPAMINE-D1 RECEPTORS BY L-DOPA OR A NOVEL DOPAMINE-D1 RECEPTOR AGONIST, A68930 [J].