PERTUSSIS-TOXIN-SENSITIVE EFFECTS OF DIPYRIDAMOLE ON RAT ATRIAL RATE

被引:1
作者
FILINGER, EJ [1 ]
ADLERGRASCHINSKY, E [1 ]
机构
[1] CONSEJO NACL INVEST CIENT & TECN,INST INVEST FARMACOL,JUNIN 956,5 PISO,RA-1113 BUENOS AIRES,ARGENTINA
来源
JOURNAL OF AUTONOMIC PHARMACOLOGY | 1993年 / 13卷 / 04期
关键词
D O I
10.1111/j.1474-8673.1993.tb00274.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1 In the spontaneously beating rat isolated atria the effects of dipyridamole (0.01, 0.1, 1 and 10 muM) and of adenosine (10 muM) on the chronotropic responses to exogenous noradrenaline (NA) were compared. 2 Dipyridamole (0.01 muM) reduced the chronotropic responses to NA throughout the entire concentration-response curve. A decrease in the maximal response to the agonist was also observed. 3 Neither the spontaneous outflow of [H-3]-NA nor its metabolic distribution were altered by dipyridamole (0.01 muM). 4 As observed with dipyridamole, the concentration-response curve to NA was shifted to the right by 10 muM adenosine. 8-Phenyltheophylline (8-PT), 10 muM prevented the decrease in the chronotropic response to NA produced by both 10 muM adenosine and 0.01 muM dipyridamole. 5 The preincubation of rat atria with 1 mug ml-1 pertussis toxin prevented the diminution in the chronotropic responses to NA produced by 0.01 muM dipyridamole. 6 The present results suggest that the decrease caused by dipyridamole in rat atrial chronotropic responses involves the participation of adenosine, probably through the interaction with type A1 adenosine receptors.
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页码:267 / 273
页数:7
相关论文
共 14 条
[1]  
ADLERGRA.E, 1972, J PHARMACOL EXP THER, V180, P286
[2]  
BERNE RM, 1983, FED PROC, V42, P3136
[3]   DIPYRIDAMOLE - POTENT STIMULATOR OF PROSTACYCLIN-(PGI2) BIOSYNTHESIS [J].
BLASS, KE ;
BLOCK, HU ;
FORSTER, W ;
PONICKE, K .
BRITISH JOURNAL OF PHARMACOLOGY, 1980, 68 (01) :71-73
[4]  
BOHM M, 1989, N-S ARCH PHARMACOL, V312, P239
[5]   INFLUENCE OF PYRIMIDOPYRIMIDINE DERIVATIVE ON DEAMINATION OF ADENOSINE BY BLOOD [J].
BUNAG, RD ;
IMAI, S ;
BERNE, RM ;
DOUGLAS, CR .
CIRCULATION RESEARCH, 1964, 15 (01) :83-&
[6]   MECHANISM OF ADENOSINE INHIBITION OF CATECHOLAMINE-INDUCED RESPONSES IN HEART [J].
DOBSON, JG .
CIRCULATION RESEARCH, 1983, 52 (02) :151-160
[7]   PREFERENTIAL METABOLISM OF (-)-H-3-NOREPINEPHRINE THROUGH DEAMINATED GLYCOL IN RAT VAS-DEFERENS [J].
GRAEFE, KH ;
STEFANO, FJE ;
LANGER, SZ .
BIOCHEMICAL PHARMACOLOGY, 1973, 22 (10) :1147-1160
[8]   8-PHENYLTHEOPHYLLINE - A POTENT P1-PURINOCEPTOR ANTAGONIST [J].
GRIFFITH, SG ;
MEGHJI, P ;
MOODY, CJ ;
BURNSTOCK, G .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1981, 75 (01) :61-64
[9]   RELEASE OF ADENOSINE FROM ANOXIC HEARTS - RELATIONSHIP TO CORONARY FLOW [J].
KATORI, M ;
BERNE, RM .
CIRCULATION RESEARCH, 1966, 19 (02) :420-&
[10]   ACTIONS OF DIPYRIDAMOLE ON ENDOGENOUS AND EXOGENOUS NORADRENALINE IN THE DOG MESENTERIC VEIN [J].
LI, YJ ;
ZHANG, GL ;
SUZUKI, H ;
KURIYAMA, H .
BRITISH JOURNAL OF PHARMACOLOGY, 1991, 102 (01) :51-56