ANTIENDOTHELIAL CELL ANTIBODIES, ENDOTHELIAL PROLIFERATION AND VON-WILLEBRAND-FACTOR ANTIGEN IN BEHCETS-DISEASE

被引：63

作者：

DIRESKENELI, H ^{[1
]}

KESER, G ^{[1
]}

DCRUZ, D ^{[1
]}

KHAMASHTA, MA ^{[1
]}

AKOGLU, T ^{[1
]}

YAZICI, H ^{[1
]}

YURDAKUL, S ^{[1
]}

HAMURYUDAN, V ^{[1
]}

OZGUN, S ^{[1
]}

GORAL, AJ ^{[1
]}

HUGHES, GRV ^{[1
]}

机构：

[1] ST THOMAS HOSP,RAYNE INST,LUPUS ARTHRITIS RES UNIT,LONDON SE1 7EH,ENGLAND

来源：

CLINICAL RHEUMATOLOGY | 1995年 / 14卷 / 01期

关键词：

BEHCETS DISEASE; ANTIENDOTHELIAL CELL ANTIBODIES; VON WILLEBRAND FACTOR ANTIGEN;

D O I：

10.1007/BF02208085

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Endothelial cell dysfunction has previously been demonstrated in Behcet's disease which has vasculitic features. In this study we investigated antiendothelial cell antibodies (AECA)and von Willebrand factor antigen (vWF) levels in patients with Behcet's disease. In vitro effects of patient sera on endothelial cell proliferation were also evaluated. AECAs were present in 29% of 70 Behcet's disease patients (Binding Index: 25+/-29% vs 9+/-7% in normal controls, p < 0.005). 95% of AECA positive patients were clinically active compared to 74% of AECA negative patients (p=0.04). Among specific organ manifestations only active arthritis correlated with AECA positivity (6 of 7 patients vs 14 of 63, p=0.002). AECA positive patients had a significantly higher mean ESR (37+/-24 mm/h vs 21+/-17 mm/h, p:0.006). Mean vWF levels were also significantly higher in patients compared to controls (166+/-75% vs 84+/-34%, p < 0.0001), No correlations were observed between AECA titres and vWF levels. No significant differences were observed between patients and controls when endothelial cell proliferation was studied (Proliferation Index: 1.25+/-0.28 vs 1.12+/-0.25, p=0.5). Our results suggest that AECA may be related to disease activity in Behcet's disease. The presence of vWF, even in patients in complete remission, might be related to factors other than endothelial damage for vWF release from endothelial cells.

引用

页码：55 / 61

页数：7

共 30 条

[1]

Muftuoglu A.U., Yurdakul S., Yazici H., Et al., Vascular involvement in Behçet's disease—a review of 129 cases, Recent Advances in Behçet's Disease, pp. 255-260, (1986)

[2]

Koc Y., Gullu I., Akpek G., Et al., Vascular involvement in Behçet's Disease, J Rheumatol, 19, pp. 402-410, (1992)

[3]

Kansu E., Sahin G., Sahin F., Sivri B., Sayek I., Batman F., Impaired prostacyclin synthesis by vessel walls in Behçet's Disease, Lancet, 2, (1986)

[4]

Cines D.B., Lyss A.P., Reeber M., Bina M., DeHoratius R.J., Presence of complement fixing anti-endothelial cell antibodies in systemic lupus erythematosus, J Clin Invest, 73, pp. 611-625, (1984)

[5]

Rosenbaum J., Pottinger B.E., Woo P., Et al., Measurement and characterization of circulating anti-endothelial cell IgG in connective tissue diseases, Clin Exp Immunol, 72, pp. 450-456, (1988)

[6]

Ferraro G., Meroni P.L., Tincani A., Et al., Anti-endothelial cell antibodies in patients with Wegener's granulomatosis and micropolyarteritis, Clin Exp Immunol, 79, pp. 47-53, (1990)

[7]

Savage C.O.S., Pottinger B.E., Gaskin G., Lockwood C.M., Pusey C.D., Pearson J.D., Vascular damage in Wegener's granulomatosis and microscopic polyarteritis: presence of anti-endothelial cell antibodies and their relation to anti-neutrophil cytoplasm antibodies, Clin Exp Immunol, 85, pp. 14-19, (1991)

[8]

D'Cruz D.P., Houssiau F.A., Ramirez G., Et al., Antibodies to endothelial cells in systemic lupus erythematosus: a potential marker for nephritis and vasculitis, Clin Exp Immunol, 85, pp. 254-261, (1991)

[9]

Del Papa N., Meroni P.L., Barcellini W., Et al., Antibodies to endothelial cells in primary vasculitides mediate in vitro endothelial cytotoxicity in the presence of normal peripheral blood mononuclear cells, Clin Immunol Immunopathol, 63, pp. 267-274, (1992)

[10]

Frampton G., Jayne D.R.W., Perry G.J., Lockwood C.M., Cameron J.S., Autoantibodies to endothelial cells and neutrophil cytoplasmic antigens in systemic vasculitis, Clin Exp Immunol, 82, pp. 227-232, (1990)

← 1 2 3 →