EFFECTS OF MATERNAL ETHANOL INGESTION ON DEVELOPMENT OF ADRENAL CATECHOLAMINES AND DOPAMINE-BETA-HYDROXYLASE IN OFFSPRING

被引：17

作者：

LAU, C ^{[1
]}

THADANI, PV ^{[1
]}

SCHANBERG, SM ^{[1
]}

SLOTKIN, TA ^{[1
]}

机构：

[1] DUKE UNIV, MED CTR, DEPT PHYSIOL & PHARMACOL, DURHAM, NC 27710 USA

来源：

NEUROPHARMACOLOGY | 1976年 / 15卷 / 08期

关键词：

D O I：

10.1016/0028-3908(76)90063-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pregnant rats were fed ethanol chronically beginning at day 13 of gestation. Adrenal catecholamines in the offspring showed a 20-30% deficit from 3-17 days of postnatal development, while adrenal dopamine-.beta.-hydroxylase activity was significantly low after 10 days of age. Upon withdrawal at 0, 3 or 5 days of age, both parameters returned to normal. Ethanol exposure possibly causes a reversible retardation in the maturation of adrenal catecholamine stores.

引用

页码：505 / 507

页数：3

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