BRAIN AMINO-ACID CONTENTS ARE DISSIMILAR IN SPORADIC AND GUAMANIAN AMYOTROPHIC-LATERAL-SCLEROSIS

被引：19

作者：

PERRY, TL

BERGERON, C

STEELE, JC

MCLACHLAN, DR

HANSEN, S

机构：

[1] GUAM MEM HOSP,TAMUNING,GU

[2] UNIV TORONTO,CTR RES NEURODEGENERAT DIS,TORONTO M5S 1A1,ONTARIO,CANADA

[3] UNIV TORONTO,DEPT PATHOL,TORONTO M5S 1A1,ONTARIO,CANADA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1990年 / 99卷 / 01期

基金：

英国医学研究理事会;

关键词：

Brain amino acids; Guamanian ALS; Parkinsonism-dementia; Sporadic amyotrophic lateral sclerosis (ALS);

D O I：

10.1016/0022-510X(90)90194-R

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Amino acid contents were measured in autopsied brains of five Guamanian patients with amyotrophic lateral sclerosis (ALS) or parkinsonism-dementia. Absence of the glutamate deficiency and taurine excess characteristic of sporadic ALS suggest that, despite clinical similarities, Guamanian ALS is a different disorder from sporadic ALS. © 1990.

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页码：3 / 8

页数：6

相关论文

共 9 条

[1] AMYOTROPHIC LATERAL SCLEROSIS AND PARKINSONS-DISEASE COMPLEX ON GUAM LINKED TO AN ENVIRONMENTAL NEUROTOXIN [J].

KURLAND, LT .

TRENDS IN NEUROSCIENCES, 1988, 11 (02) :51-54

[2] INTRA-NEURONAL ALUMINUM ACCUMULATION IN AMYOTROPHIC LATERAL SCLEROSIS AND PARKINSONISM-DEMENTIA OF GUAM [J].

PERL, DP ;

GAJDUSEK, DC ;

GARRUTO, RM ;

YANAGIHARA, RT ;

GIBBS, CJ .

SCIENCE, 1982, 217 (4564) :1053-1055

[3] BRAIN GLUTAMATE DEFICIENCY IN AMYOTROPHIC-LATERAL-SCLEROSIS [J].

PERRY, TL ;

HANSEN, S ;

JONES, K .

NEUROLOGY, 1987, 37 (12) :1845-1848

[4] POSTMORTEM CHANGES OF AMINO-COMPOUNDS IN HUMAN AND RAT-BRAIN [J].

PERRY, TL ;

HANSEN, S ;

GANDHAM, SS .

JOURNAL OF NEUROCHEMISTRY, 1981, 36 (02) :406-412

[5] THE NEUROEXCITOTOXIC AMINO-ACIDS GLUTAMATE AND ASPARTATE ARE ALTERED IN THE SPINAL-CORD AND BRAIN IN AMYOTROPHIC LATERAL SCLEROSIS [J].

PLAITAKIS, A ;

CONSTANTAKAKIS, E ;

SMITH, J .

ANNALS OF NEUROLOGY, 1988, 24 (03) :446-449

[6] AMYOTROPHIC-LATERAL-SCLEROSIS AND PARKINSONISM-DEMENTIA ON GUAM - A 30-YEAR EVALUATION OF CLINICAL AND NEUROPATHOLOGIC TRENDS [J].

RODGERSJOHNSON, P ;

GARRUTO, RM ;

YANAGIHARA, R ;

CHEN, KM ;

GAJDUSEK, DC ;

GIBBS, CJ .

NEUROLOGY, 1986, 36 (01) :7-13

[7] IMMUNOCYTOCHEMICAL CHARACTERIZATION OF NEUROFIBRILLARY TANGLES IN AMYOTROPHIC LATERAL SCLEROSIS AND PARKINSONISM-DEMENTIA OF GUAM [J].

SHANKAR, SK ;

YANAGIHARA, R ;

GARRUTO, RM ;

GRUNDKEIQBAL, I ;

KOSIK, KS ;

GAJDUSEK, DC .

ANNALS OF NEUROLOGY, 1989, 25 (02) :146-151

[8] GUAM AMYOTROPHIC-LATERAL-SCLEROSIS PARKINSONISM DEMENTIA LINKED TO A PLANT EXCITANT NEUROTOXIN [J].

SPENCER, PS ;

NUNN, PB ;

HUGON, J ;

LUDOLPH, AC ;

ROSS, SM ;

ROY, DN ;

ROBERTSON, RC .

SCIENCE, 1987, 237 (4814) :517-522

[9] PREPARATION OF L- AND D-ALPHA-AMINO-BETA-METHYLAMINOPROPIONIC ACIDS AND IDENTIFICATION OF COMPOUND ISOLATED FROM CYCAS CIRCINALIS AS L-ISOMER [J].

VEGA, A ;

BELL, EA ;

NUNN, PB .

PHYTOCHEMISTRY, 1968, 7 (10) :1885-&