MUTATIONAL ANALYSIS OF ENHANCER DOMAINS RESPONSIVE TO TRANSACTIVATION BY THE X-GENE OF HUMAN HEPATITIS B-VIRUS

被引：5

作者：

GOODARZI, G ^{[1
]}

OHNO, H ^{[1
]}

ADAMS, R ^{[1
]}

DARABI, A ^{[1
]}

TEWARI, A ^{[1
]}

WATABE, M ^{[1
]}

WATABE, K ^{[1
]}

机构：

[1] SO ILLINOIS UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,SPRINGFIELD,IL 62708

来源：

ARCHIVES OF VIROLOGY | 1990年 / 114卷 / 3-4期

关键词：

D O I：

10.1007/BF01310752

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The X gene product of human hepatitis B virus (HBV) trans-activates the HBV enhancer. In order to identify domains responsive to trans-activation by the X gene, we introduced a series of mutations into the HBV enhancer and assayed the enhancer activities in the presence of the X gene product. Our results suggest that the EP domain of the enhancer is essential for trans-activation by the X gene. © 1990 Springer-Verlag.

引用

页码：237 / 242

页数：6

共 23 条

[1] BEASLEY RP, 1981, LANCET, V2, P1129
[2] CELLULAR FACTORS THAT INTERACT WITH THE HEPATITIS-B VIRUS ENHANCER
BENLEVY, R
FAKTOR, O
BERGER, I
SHAUL, Y
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (04) : 1804 - 1809
[3] BENLEVY R, 1990, J VIROL, V64, P1861
[4] BODBOUT R, 1988, MOL CELL BIOL, V8, P1169
[5] SUPERCOIL SEQUENCING - A FAST AND SIMPLE METHOD FOR SEQUENCING PLASMID DNA
CHEN, EY
SEEBURG, PH
[J]. DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1985, 4 (02): : 165 - 170
[6] BINDING OF TISSUE-SPECIFIC FACTORS TO THE ENHANCER SEQUENCE OF HEPATITIS-B VIRUS
CHOU, HW
HARRELL, D
FOROUGH, R
WATABE, K
[J]. FEBS LETTERS, 1988, 229 (02) : 349 - 354
[7] TRANSCRIPTIONAL ACTIVATION OF HOMOLOGOUS AND HETEROLOGOUS GENES BY THE HEPATITIS-B VIRUS X-GENE PRODUCT IN CELLS PERMISSIVE FOR VIRAL REPLICATION
COLGROVE, R
SIMON, G
GANEM, D
[J]. JOURNAL OF VIROLOGY, 1989, 63 (09) : 4019 - 4026
[8] RECOMBINANT GENOMES WHICH EXPRESS CHLORAMPHENICOL ACETYLTRANSFERASE IN MAMMALIAN-CELLS
GORMAN, CM
MOFFAT, LF
HOWARD, BH
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1982, 2 (09) : 1044 - 1051
[9] RAPID AND EFFICIENT SITE-SPECIFIC MUTAGENESIS WITHOUT PHENOTYPIC SELECTION
KUNKEL, TA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (02) : 488 - 492
[10] EXPRESSION OF THE HEPATITIS B-VIRUS SURFACE-ANTIGEN GENE IN CELL-CULTURE BY USING A SIMIAN VIRUS-40 VECTOR
MORIARTY, AM
HOYER, BH
SHIH, JWK
GERIN, JL
HAMER, DH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (04): : 2606 - 2610

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