THE MOUSE POLYCYSTIC KIDNEY-DISEASE MUTATION (CPK) IS LOCATED ON PROXIMAL CHROMOSOME 12

被引：40

作者：

DAVISSON, MT

GUAYWOODFORD, LM

HARRIS, HW

DEUSTACHIO, P

机构：

[1] HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115

[2] HARVARD UNIV,CHILDRENS HOSP,SCH MED,DIV NEPHROL,BOSTON,MA 02115

[3] NYU MED CTR,DEPT BIOCHEM,NEW YORK,NY 10016

来源：

GENOMICS | 1991年 / 9卷 / 04期

关键词：

D O I：

10.1016/0888-7543(91)90376-P

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The mouse congenital polycystic kidney (cpk) mutation produces a condition that resembles human autosomal recessive polycystic kidney disease (ARPKD) in its pattern of inheritance, clinical progression, and histopathology. Inheritance of this mouse mutation in crosses segregating the Rb(12.14)8Rma translocation chromosome and various DNA markers of Chromosome 12 have localized cpk to a site near D12Nyu2, approximately 7 cM from the centromere of Chromosome 12. This result suggests that the homologous PKD2 gene should be localized to either human chromosome 2p23-p25 or chromosome 7q22-q31. © 1991.

引用

页码：778 / 781

页数：4

共 29 条

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[2]

BLANK RD, 1988, GENETICS, V120, P1073

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