UBIQUITIN IMMUNOREACTIVITY IN KURU PLAQUES IN CREUTZFELDT-JAKOB DISEASE

被引：23

作者：

SUENAGA, T

HIRANO, A

LLENA, JF

KSIEZAKREDING, H

YEN, SH

DICKSON, DW

机构：

[1] MONTEFIORE MED CTR,DEPT PATHOL,DIV NEUROPATHOL,111 E 210TH ST,BRONX,NY 10467

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PATHOL NEUROPATHOL,BRONX,NY 10461

[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED,ROSE F KENNEDY CTR RES MENT RETARDAT & HUMAN DEV,BRONX,NY 10461

来源：

ANNALS OF NEUROLOGY | 1990年 / 28卷 / 02期

关键词：

D O I：

10.1002/ana.410280210

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebellar kuru plaques in 2 cases of Creutzfeldt‐Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin‐positive, tau‐negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt‐Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques. Copyright © 1990 American Neurological Association

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页码：174 / 177

页数：4

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