A POINT MUTATION WITHIN A DISTINCT CONSERVED REGION OF THE HERPES-SIMPLEX VIRUS-DNA POLYMERASE GENE CONFERS DRUG-RESISTANCE

被引：101

作者：

HWANG, CBC ^{[1
]}

RUFFNER, KL ^{[1
]}

COEN, DM ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 03期

关键词：

D O I：

10.1128/JVI.66.3.1774-1776.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have shown that a drug-resistant mutant from a clinical isolate of herpes simplex virus contains a single point mutation in the DNA polymerase gene that confers resistance to both acyclovir and foscarnet. The mutated amino acid is located within a distinct conserved region shared among alpha-like DNA polymerases which we designate region VII. We infer that these conserved sequences are directly or indirectly involved in the recognition and binding of nucleotide and PP(i) substrates.

引用

页码：1774 / 1776

页数：3

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