EXPRESSION OF THYROID-HORMONE RECEPTOR ISOFORMS IN RAT OLIGODENDROCYTE CULTURES - EFFECT OF 3,5,3'-TRIIODO-L-THYRONINE

被引：36

作者：

BAAS, D

FRESSINAUD, C

ITTEL, ME

REEBER, A

DALENCON, D

PUYMIRAT, J

SARLIEVE, LL

机构：

[1] CTR NEUROCHIM,NEUROBIOL MOLEC INTERACT CELLULAIRES LAB,CNRS,UPR 416,F-67084 STRASBOURG,FRANCE

[2] CHRU ANGERS,SERV NEUROL B,F-49033 ANGERS,FRANCE

[3] CHU LAVAL,ST FOY G1V 4G2,PQ,CANADA

来源：

NEUROSCIENCE LETTERS | 1994年 / 176卷 / 01期

关键词：

OLIGODENDROCYTE CULTURE; O-2A PROGENITOR; THYROID HORMONE; TRIIODOTHYRONINE RECEPTORS; IMMUNOLABELING; MESSENGER-RNA;

D O I：

10.1016/0304-3940(94)90868-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

3,5,3'-Triiodo-L-thyronine (T-3) acts at the genomic level by interacting with nuclear T-3 receptors (T(3)Rs). We have used double immunostaining to follow the expression of T(3)Rs and oligodendrocytes (OL) lineage markers in rat secondary cultures consisting of 85-90% OL. Using antibodies against different synthetic peptides of T(3)Rs (alpha common: alpha 1 + alpha 2 and pi) we find that alpha-T(3)R is expressed in both O-2A progenitors and in mature OL, while beta 1-T(3)R is expressed only in mature OL. In cultured OL, beta 1-T(3)R mRNA is upregulated the most by T-3. OL exhibit more numerous and longer processes when treated by T-3.

引用

页码：47 / 51

页数：5

共 29 条

[1] TRIIODOTHYRONINE STIMULATION OF OLIGODENDROGLIAL DIFFERENTIATION AND MYELINATION - A DEVELOPMENTAL-STUDY [J].