MOLECULAR MECHANISMS OF ANTIVIRAL RESISTANCE

被引:54
作者
KIMBERLIN, DW
COEN, DM
BIRON, KK
COHEN, JI
LAMB, RA
MCKINLAY, M
EMINI, EA
WHITLEY, RJ
机构
[1] HARVARD UNIV, SCH MED, DEPT BIOL CHEM & MOLEC PHARMACOL, BOSTON, MA USA
[2] BURROUGHS WELLCOME CO, RES TRIANGLE PK, NC 27709 USA
[3] NIH, BETHESDA, MD 20892 USA
[4] HOWARD HUGHES MED INST, EVANSTON, IL USA
[5] NORTHWESTERN UNIV, EVANSTON, IL USA
[6] VIROPHARMA, COLLEGEVILLE, PA USA
[7] MERCK RES LABS, West Point, PA USA
关键词
D O I
10.1016/0166-3542(95)00027-J
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
[No abstract available]
引用
收藏
页码:369 / 401
页数:33
相关论文
共 129 条
[1]   3-DIMENSIONAL STRUCTURES OF DRUG-RESISTANT MUTANTS OF HUMAN RHINOVIRUS 14 [J].
BADGER, J ;
KRISHNASWAMY, S ;
KREMER, MJ ;
OLIVEIRA, MA ;
ROSSMANN, MG ;
HEINZ, BA ;
RUECKERT, RR ;
DUTKO, FJ ;
MCKINLAY, MA .
JOURNAL OF MOLECULAR BIOLOGY, 1989, 207 (01) :163-174
[2]   A 3-NUCLEOTIDE DELETION IN THE UL97 OPEN READING FRAME IS RESPONSIBLE FOR THE GANCICLOVIR RESISTANCE OF A HUMAN CYTOMEGALOVIRUS CLINICAL ISOLATE [J].
BALDANTI, F ;
SILINI, E ;
SARASINI, A ;
TALARICO, CL ;
STANAT, SC ;
BIRON, KK ;
FURIONE, M ;
BONO, F ;
PALU, G ;
GERNA, G .
JOURNAL OF VIROLOGY, 1995, 69 (02) :796-800
[3]   HUMAN-IMMUNODEFICIENCY-VIRUS-1 (HIV-1)-SPECIFIC REVERSE-TRANSCRIPTASE (RT) INHIBITORS MAY SUPPRESS THE REPLICATION OF SPECIFIC DRUG-RESISTANT (E138K)RT HIV-1 MUTANTS OR SELECT FOR HIGHLY RESISTANT (Y181C-]C181I)RT HIV-1 MUTANTS [J].
BALZARINI, J ;
KARLSSON, A ;
SARDANA, VV ;
EMINI, EA ;
CAMARASA, MJ ;
DECLERCQ, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6599-6603
[4]   TREATMENT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)-INFECTED CELLS WITH COMBINATIONS OF HIV-1-SPECIFIC INHIBITORS RESULTS IN A DIFFERENT RESISTANCE PATTERN THAN DOES TREATMENT WITH SINGLE-DRUG THERAPY [J].
BALZARINI, J ;
KARLSSON, A ;
PEREZPEREZ, MJ ;
CAMARASA, MJ ;
TARPLEY, WG ;
DECLERCQ, E .
JOURNAL OF VIROLOGY, 1993, 67 (09) :5353-5359
[5]  
BALZARINI J, 1993, MOL PHARMACOL, V43, P109
[6]   HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) STRAINS SELECTED FOR RESISTANCE AGAINST THE HIV-1-SPECIFIC [2',5'-BIS-O-(TERT-BUTYLDIMETHYLSILYL)-3'-SPIRO-5''-(4''-AMINO-1'',2''-OXATHIOLE-2'',2''-DIOXIDE)]-BETA-D-PENTOFURANOSYL (TSAO) NUCLEOSIDE ANALOGS RETAIN SENSITIVITY TO HIV-1-SPECIFIC NONNUCLEOSIDE INHIBITORS [J].
BALZARINI, J ;
KARLSSON, A ;
VANDAMME, AM ;
PEREZPEREZ, MJ ;
ZHANG, H ;
VRANG, L ;
OBERG, B ;
BACKBRO, K ;
UNGE, T ;
SANFELIX, A ;
VELAZQUEZ, S ;
CAMARASA, MJ ;
DECLERCQ, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) :6952-6956
[7]   HIV-1-SPECIFIC REVERSE-TRANSCRIPTASE INHIBITORS SHOW DIFFERENTIAL ACTIVITY AGAINST HIV-1 MUTANT STRAINS CONTAINING DIFFERENT AMINO-ACID SUBSTITUTIONS IN THE REVERSE-TRANSCRIPTASE [J].
BALZARINI, J ;
KARLSSON, A ;
PEREZPEREZ, MJ ;
VRANG, L ;
WALBERS, J ;
ZHANG, H ;
OBERG, B ;
VANDAMME, AM ;
CAMARASA, MJ ;
DECLERCQ, E .
VIROLOGY, 1993, 192 (01) :246-253
[8]  
BALZARINI J, 1993, MOL PHARMACOL, V44, P694
[9]   GENETIC-BASIS OF RESISTANCE TO RIMANTADINE EMERGING DURING TREATMENT OF INFLUENZA-VIRUS INFECTION [J].
BELSHE, RB ;
SMITH, MH ;
HALL, CB ;
BETTS, R ;
HAY, AJ .
JOURNAL OF VIROLOGY, 1988, 62 (05) :1508-1512
[10]   A HUMAN CYTOMEGALOVIRUS MUTANT RESISTANT TO THE NUCLEOSIDE ANALOG 9-([2-HYDROXY-1-(HYDROXYMETHYL)ETHOXY]METHYL)GUANINE (BW B759U) INDUCES REDUCED LEVELS OF BW B759U TRIPHOSPHATE [J].
BIRON, KK ;
FYFE, JA ;
STANAT, SC ;
LESLIE, LK ;
SORRELL, JB ;
LAMBE, CU ;
COEN, DM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (22) :8769-8773