DEMONSTRATION OF PNEUMOLYSIN ANTIBODIES IN CIRCULATING IMMUNE-COMPLEXES - A NEW DIAGNOSTIC METHOD FOR PNEUMOCOCCAL PNEUMONIA

被引：55

作者：

LEINONEN, M

SYRJALA, H

JALONEN, E

KUJALA, P

HERVA, E

机构：

[1] National Public Health Institute, SF-00300 Helsinki

[2] National Public Health Institute, Oulu

[3] Department of Medicine, University Central Hospital, Oulu

来源：

SERODIAGNOSIS AND IMMUNOTHERAPY IN INFECTIOUS DISEASE | 1990年 / 4卷 / 06期

关键词：

IMMUNE COMPLEXES; PNEUMOLYSIN; PNEUMONIA;

D O I：

10.1016/0888-0786(90)90058-V

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We isolated immune complexes (IC) from the sera obtained from 129 adult patients with community-acquired pneumonia and from 120 healthy controls and measured antibodies to pneumococcal pneumolysin in dissociated complexes. None of the healthy controls had demonstrable pneumolysin-specific IC in their sera irrespective of whether they had high or low serum antibody titers to pneumolysin. By contrast, 62 (48%) of pneumonia patients had pneumolysin-IC in one or more of serum specimens. All 11 patients with positive blood culture for pneumococcus and 86% of those in whom pneumococcal involvement was suggested by culture or antigen detection in sputum or who showed serum antibody response to pneumolysin had pneumolysin antibodies in circulating IC. In addition, pneumolysin-IC were detected in 17 patients without other evidence of pneumococcal infection. The lack of pneumolysin-IC in healthy controls and their presence in patients with pneumococcal pneumonia suggest that the demonstration pneumolysin-IC is a sensitive, reliable method for the diagnosis of pneumococcal pneumonia. © 1990.

引用

页码：451 / 458

页数：8

共 12 条

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