CLINICAL AND EPIDEMIOLOGIC ASPECTS OF ALZHEIMERS-DISEASE WITH PRESENILE ONSET - A CASE CONTROL STUDY

被引：66

作者：

FERINISTRAMBI, L

SMIRNE, S

GARANCINI, P

PINTO, P

FRANCESCHI, M

机构：

[1] Neurology Department, Milan

[2] Epidemiology Unit, Milan University School of Medicine, Milan, instituto Scientifico ospedale san raffale

来源：

NEUROEPIDEMIOLOGY | 1990年 / 9卷 / 01期

关键词：

Alzheimer’s disease; Case control study; Epidemiology;

D O I：

10.1159/000110750

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Little is known regarding the pathogenetic factors for Alzheimer’s disease (AD). We studied 63 AD patients in order to evaluate if there were clinical subtypes of AD and whether prior illnesses and life-styles were involved in the development of the disease. In our patients selected for onset of symptoms before age 65 we did not find any significant clinical heterogeneity. Furthermore, we found no data in the medical history that are predictive for the development of presenile AD but observed a significantly increased frequency of dementia in the families of AD patients in comparison to controls. © 1990 S. Karger AG, Basel.

引用

页码：39 / 49

页数：11

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