REACTIVE OXYGEN INTERMEDIATES METABOLIZING ENZYMES IN ANCYLOSTOMA-CEYLANICUM AND NIPPOSTRONGYLUS-BRASILIENSIS

被引：22

作者：

BATRA, S ^{[1
]}

SINGH, SP ^{[1
]}

GUPTA, S ^{[1
]}

KATIYAR, JC ^{[1
]}

SRIVASTAVA, VML ^{[1
]}

机构：

[1] CENT DRUG RES INST,DIV BIOCHEM,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 8卷 / 03期

关键词：

A; ceylanicum; Free radicals; Glutathione peroxidase; N; brasiliensis; Superoxide dismutase; Catalase; Xanthine oxidase;

D O I：

10.1016/0891-5849(90)90074-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adult worms of Ancylostoma ceylanicum and Nippostrongylus brasiliensis were found to possess an active system for the detoxification of reactive oxygen intermediates. Xanthine oxidase, which is known to produce superoxide anion, was detected in both the nematode parasites in significant activities. Superoxide anion, thus produced, may quickly be eliminated by superoxide dismutase. Both parasites also exhibited the presence of catalase, peroxidase, and glutathione peroxidase for efficient removal of hydrogen peroxide. Glutathione reductase and glucose-6-phosphate dehydrogenase were, however, detected in low levels of activities. Endowment of A. ceylanicum and N. brasiliensis with these antioxidant enzymes, therefore, enables them to evade the host's effector mechanism for their survival. Superoxide dismutase of both these nematodes showed marked inhibition by KCN and, hence, the enzyme appears to be of copper-zinc type. © 1990.

引用

页码：271 / 274

页数：4

共 27 条

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