A NEW APPROACH TO THE STEREOSPECIFIC SYNTHESIS OF A DIHYDROXYETHYLENE ISOSTERE

被引:18
作者
ATSUUMI, S
NAKANO, M
KOIKE, Y
TANAKA, S
FUNABASHI, H
HASHIMOTO, J
MORISHIMA, H
机构
[1] Chemistry Of Natural Products, Exploratory Research Laboratories, Banyu Pharmaceutical Co., Ltd, Tokyo 153, 2-9-3, Shimomegruo, Meguro-ku
关键词
RENIN INHIBITOR; DIHYDROXYETHYLENE ISOSTERE; STEREOSPECIFIC SYNTHESIS; DIVINYLCARBINOL; SHARPLESS EPOXIDATION; (2S,3R,4S)-4-AMINO-5-CYCLOHEXYL-1-MORPHOLINO-2,3-PENTANEDIOL;
D O I
10.1248/cpb.38.3460
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A dihydroxyethylene isostere, (2S,3R,4S)-4-amino-5-cyclohexyl-1-morpholino-2,3-pentanediol, which is a component of non-peptidic, orally active, low-molecular-weight renin inhibitors, was synthesized sterospecifically starting from prochiral divinylcarbinol via the Sharpless epoxidation.
引用
收藏
页码:3460 / 3462
页数:3
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