PHOTOCHEMICAL STROKE AND BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) MESSENGER-RNA EXPRESSION

被引：37

作者：

COMELLI, MC ^{[1
]}

SEREN, MS ^{[1
]}

GUIDOLIN, D ^{[1
]}

MANEV, RM ^{[1
]}

FAVARON, M ^{[1
]}

RIMLAND, JM ^{[1
]}

CANELLA, R ^{[1
]}

NEGRO, A ^{[1
]}

MANEV, H ^{[1
]}

机构：

[1] FIDIA RES LABS,VIA PONTE FABBRICA 3-A,I-35031 ABANO TERME,ITALY

来源：

NEUROREPORT | 1992年 / 3卷 / 06期

关键词：

STROKE; PHOTOTHROMBOSIS; BDNF; MK-801; GLUTAMATE; EXCITOTOXICITY;

D O I：

10.1097/00001756-199206000-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

IN SITU hybridization and Northern blotting were used to study the expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat brain following photochemical stroke. A focal thrombotic lesion of the sensorimotor cortex was produced by intravenously injecting the light-sensitive dye rose bengal and exposing the skull to a controlled beam of light. Four hours after the light exposure the level of BDNF mRNA was increased in the hippocampus and cortex ipsilateral and perifocal to the lesion. The stroke-induced BDNF mRNA increase was prevented by the non-competitive glutamate receptor blocker dizocilpine (MK-801). The results indicate that the activation of N-methyl-D-aspartate (NMDA)-sensitive glutamate receptors is involved in the stroke-triggered stimulation of BDNF mRNA increase.

引用

页码：473 / 476

页数：4

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