PROLONGED HEMOLYTIC-ANEMIA IN MALARIA AND AUTOANTIBODIES AGAINST TRIOSEPHOSPHATE ISOMERASE

被引：42

作者：

RITTER, K ^{[1
]}

KUHLENCORD, A ^{[1
]}

THOMSSEN, R ^{[1
]}

BOMMER, W ^{[1
]}

机构：

[1] UNIV GOTTINGEN,DEPT TROP MED,D-37075 GOTTINGEN,GERMANY

来源：

LANCET | 1993年 / 342卷 / 8883期

关键词：

D O I：

10.1016/0140-6736(93)92248-R

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Prolonged haemolysis may accompany infection with Plasmodium falciparum. We observed prolonged haemolysis in 4 of 10 patients with this type of malaria after parasitological cure. IgM antibodies specific for the glycolytic enzyme triosephosphate isomerase were detected in these patients' sera. Clinical recovery and a decrease in haemolysis coincided with a fall in these autoantibodies. In vitro, affinity purified autoantibodies isolated from the sera directed against triosephosphate isomerase induced lysis of erythrocytes and activation of complement as shown by the Cr-51 release assay. We assume that autoantibodies against triosephosphate isomerase contribute to the development of prolonged haemolysis and anaemia in P. falciparum malaria.

引用

页码：1333 / 1334

页数：2

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