A MECHANISM OF RESISTANCE TO METHOTREXATE - NADPH BUT NOT NADH STIMULATION OF METHOTREXATE BINDING TO DIHYDROFOLATE-REDUCTASE

被引：14

作者：

KAMEN, BA ^{[1
]}

WHYTEBAUER, W ^{[1
]}

BERTINO, JR ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,DEPT PHARMACOL,NEW HAVEN,CT 06510

来源：

BIOCHEMICAL PHARMACOLOGY | 1983年 / 32卷 / 12期

关键词：

D O I：

10.1016/0006-2952(83)90047-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：1837 / 1841

页数：5

共 20 条

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[3]

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[4]

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[5] DIHYDROFOLATE-REDUCTASE FROM A RESISTANT SUBLINE OF L1210 LYMPHOMA - PURIFICATION BY AFFINITY CHROMATOGRAPHY AND UV DIFFERENCE SPECTROPHOTOMETRIC AND CIRCULAR DICHROIC STUDIES [J].

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[6] RAPID RADIOMETRIC ASSAY FOR DIHYDROFOLATE-REDUCTASE [J].

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[8]

HUENNEKENS FM, 1973, ADV ENZYME REGULAT, V12, P131

[9] RAPID, RADIOCHEMICAL LIGAND BINDING ASSAY FOR METHOTREXATE [J].

KAMEN, BA ;

TAKACH, PL ;

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CASTON, JD .

ANALYTICAL BIOCHEMISTRY, 1976, 70 (01) :54-63

[10]

KAMEN BA, 1980, J BIOL CHEM, V255, P3254

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