PEPTIDE-CONTAINING NERVES IN THE HUMAN PREGNANT UTERINE CERVIX - AN IMMUNOHISTOCHEMICAL STUDY EXPLORING THE EFFECT OF RU-486 (MIFEPRISTONE)

被引：15

作者：

FRIED, G

MEISTER, B

RADESTAD, A

机构：

[1] Departments of Obstetrics and Gynaecology, Karolinska Institutet

[2] Department of Physiology, Karolinska Institutet

[3] Department of Histology and Neurobiology, Karolinska Institutet

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 07期

关键词：

Calcitonin gene-related peptide; Galanin; Neuropeptide Y; Somatostatin; Vasocative intestinal polypeptide;

D O I：

10.1093/oxfordjournals.humrep.a137200

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The presence of several neuropeptides (neuropeptide Y (NPY), vaseactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP), substance P (SP), galanin (GAL), enkephalin (ENK), somatostatin (SOM)) was established in the early pregnant human cervix using indirect immunofluorescence immunohistochemistry. Several peptides (VIP, NPY, CGRP, GAL) were present both in free nerves among smooth muscle cells and around blood vessels. Others (SP, SOM) were only seen as single varicosities among smooth muscle cells. Randomized treatment of patients with RU 486 (mifepristone) prior to surgical sampling revealed no clearcut difference in peptide Immunoreactivities. After RU 486 treatment, however, there was a tendency towards a decrease of NPY- and VIP-immunoreactivity, and an increase of CGRP-immunoreactivity. © 1990 Oxford University Press.

引用

页码：870 / 876

页数：7

共 62 条

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