1-ALPHA,25-DIHYDROXY-19-NOR-VITAMIN-D3, A NOVEL VITAMIN-D-RELATED COMPOUND WITH POTENTIAL THERAPEUTIC ACTIVITY

被引：152

作者：

PERLMAN, KL ^{[1
]}

SICINSKI, RR ^{[1
]}

SCHNOES, HK ^{[1
]}

DELUCA, HF ^{[1
]}

机构：

[1] UNIV WISCONSIN,COLL AGR & LIFE SCI,DEPT BIOCHEM,MADISON,WI 53706

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(00)98795-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1α,25-Dihydroxy-19-nor-vitamin D3 has been synthesized via oxidative degradation of the 1α-hydroxycylcovitamin intermediate. Preliminary studies indicate that the new analog induces the differentiation of human leukemia HL-60 cells, with little or no calcemic activity. © 1990 Pergamon Press plc.

引用

页码：1823 / 1824

页数：2

共 4 条

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OSTREM, VK ;

TANAKA, Y ;

PRAHL, J ;

DELUCA, HF ;

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (09) :2610-2614

[2] ELECTROPHILIC ADDITION OF OSO4 TO 25-HYDROXYCHOLECALIFEROL AND ITS 3,5-CYCLO DERIVATIVE [J].

PAAREN, HE ;

SCHNOES, HK ;

DELUCA, HF .

JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (21) :3819-3820

[3] DIRECT C(1) HYDROXYLATION OF VITAMIN-D3 AND RELATED-COMPOUNDS [J].

PAAREN, HE ;

DELUCA, HF ;

SCHNOES, HK .

JOURNAL OF ORGANIC CHEMISTRY, 1980, 45 (16) :3253-3258

[4]

SAI H, 1986, CHEM PHARM BULL, V34, P4508

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