AUTOMATIC DETECTION OF SPONTANEOUS SYNAPTIC RESPONSES IN CENTRAL NEURONS

被引:86
作者
ANKRI, N
LEGENDRE, P
FABER, DS
KORN, H
机构
[1] INST PASTEUR,DEPT BIOTECHNOL,NEUROBIOL CELLULAIRE LAB,INSERM,U261,F-75724 PARIS 15,FRANCE
[2] MED COLL PENN,DEPT ANAT & NEUROBIOL,PHILADELPHIA,PA 19129
基金
美国国家卫生研究院;
关键词
SIGNAL ANALYSIS; AUTOMATIC DETECTION; AUTOMATIC MEASUREMENT; TEMPLATE RECOGNITION; SYNAPTIC NOISE; QUANTUM; SIMULATED SPONTANEOUS ACTIVITY;
D O I
10.1016/0165-0270(94)90060-4
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A fully automatized software package for detection and measurements of randomly occurring synaptic transients embedded in background noise is described. It is based on waveform recognition protocols, allows analysis of long data segments, and provides quantitative information about event amplitudes and kinetics. Simulated postsynaptic recordings have been used to assess its performance over a wide range of conditions mimicking those seen in physiological experiments.
引用
收藏
页码:87 / 100
页数:14
相关论文
共 18 条
  • [1] ORIGIN OF VARIABILITY IN QUANTAL SIZE IN CULTURED HIPPOCAMPAL-NEURONS AND HIPPOCAMPAL SLICES
    BEKKERS, JM
    RICHERSON, GB
    STEVENS, CF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) : 5359 - 5362
  • [2] QUANTAL COMPONENTS OF THE END-PLATE POTENTIAL
    DELCASTILLO, J
    KATZ, B
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1954, 124 (03): : 560 - 573
  • [3] DELCOMYN F, 1992, METHODS NEUROSCIENCE, V10, P217
  • [4] QUANTAL ANALYSIS OF INHIBITORY SYNAPTIC TRANSMISSION IN THE DENTATE GYRUS OF RAT HIPPOCAMPAL SLICES - A PATCH-CLAMP STUDY
    EDWARDS, FA
    KONNERTH, A
    SAKMANN, B
    BUSCH, C
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1990, 430 : 213 - +
  • [5] INTRINSIC QUANTAL VARIABILITY DUE TO STOCHASTIC PROPERTIES OF RECEPTOR-TRANSMITTER INTERACTIONS
    FABER, DS
    YOUNG, WS
    LEGENDRE, P
    KORN, H
    [J]. SCIENCE, 1992, 258 (5087) : 1494 - 1498
  • [6] SYNAPTIC NOISE AND MULTIQUANTAL RELEASE AT DENDRITIC SYNAPSES
    KORN, H
    BAUSELA, F
    CHARPIER, S
    FABER, DS
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1993, 70 (03) : 1249 - 1254
  • [7] TRANSMISSION AT A CENTRAL INHIBITORY SYNAPSE .4. QUANTAL STRUCTURE OF SYNAPTIC NOISE
    KORN, H
    FABER, DS
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1990, 63 (01) : 198 - 222
  • [8] QUANTAL ANALYSIS AND SYNAPTIC EFFICACY IN THE CNS
    KORN, H
    FABER, DS
    [J]. TRENDS IN NEUROSCIENCES, 1991, 14 (10) : 439 - 445
  • [9] SPONTANEOUS QUANTAL CURRENTS IN A CENTRAL NEURON MATCH PREDICTIONS FROM BINOMIAL ANALYSIS OF EVOKED-RESPONSES
    KORN, H
    BURNOD, Y
    FABER, DS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (16) : 5981 - 5985
  • [10] MINTZ I, 1991, J NEUROSCI, V11, P3359