FUNCTIONAL CONSERVATION OF THE SALMONELLA AND SHIGELLA EFFECTORS OF ENTRY INTO EPITHELIAL-CELLS

被引：108

作者：

HERMANT, D

MENARD, R

ARRICAU, N

PARSOT, C

POPOFF, MY

机构：

[1] INST PASTEUR,UNITE ENTEROBACTERIES,F-75724 PARIS 15,FRANCE

[2] INST PASTEUR,INSERM,UNITE 389,F-75724 PARIS 15,FRANCE

[3] INST PASTEUR,UNITE PATHOGENIE MICROBIENNE MOLEC,F-75724 PARIS 15,FRANCE

来源：

MOLECULAR MICROBIOLOGY | 1995年 / 17卷 / 04期

关键词：

D O I：

10.1111/j.1365-2958.1995.mmi_17040781.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A Salmonella typhi chromosomal locus composed of five adjacent genes, designated sipEBCDA, was identified by transposon mutagenesis as being essential for cell invasion. Products of the sip genes exhibit. extensive sequence similarities to the effecters of Shigella entry into epithelial cells encoded by the virulence plasmid-borne ipa operon. Expression of sipE and sipB in a Shigella non-invasive ipaB mutant restored the ability to invade epithelial cells. The structural and functional conservation of the Sip and Ipa proteins suggests that Salmonella and Shigella entry processes are promoted by similar effecters.

引用

页码：781 / 789

页数：9

共 49 条

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