LIQUID-LIKE SIDE-CHAIN DYNAMICS IN MYOGLOBIN

被引：83

作者：

KNELLER, GR

SMITH, JC

机构：

[1] IBM FRANCE,F-75012 PARIS,FRANCE

[2] CEA SACLAY,SBPM,DBCM,F-91191 GIF SUR YVETTE,FRANCE

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1994年 / 242卷 / 03期

关键词：

PROTEIN DYNAMICS; NEUTRON SCATTERING; MOLECULAR DYNAMICS; MYOGLOBIN;

D O I：

10.1006/jmbi.1994.1570

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

At temperatures above similar to 200 K the motions of atoms in globular proteins contain a non-vibrational component that gives rise to characteristic elastic and quasi-elastic neutron scattering profiles. There is evidence that the non-vibrational dynamics is required for protein function. Here we show by analysing a molecular dynamics simulation of myoglobin that the neutron scattering results from liquid-like rigid-body motion of the protein side-chains.

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收藏

页码：181 / 185

页数：5

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