INHALABILITY OF LARGE PARTICLES INTO THE HUMAN NASAL PASSAGE - INVIVO STUDIES IN STILL AIR

被引:23
作者
BREYSSE, PN [1 ]
SWIFT, DL [1 ]
机构
[1] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DIV ENVIRONM HLTH ENGN,615 N WOLFE ST,BALTIMORE,MD 21205
关键词
D O I
10.1080/02786829008959460
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
The aspiration of large particles (18–30.5 μm) in the human nose was studied to determine the inhalation efficiency as a function of particle size, and to evaluate the upper size cutoff for inhalable particles in still air. Under these conditions, the ability of a particle to be inhaled is dependent on the inhalation velocity entering the nose and the particle terminal settling velocity. Nasal inhalation of radiolabeled pollen and wood dust aerosols was measured in four subjects at normal resting breathing rates. The efficiency of nasal aspiration was found to decrease as the square of the particle size. The upper size cutoff for inhalability was estimated to be approximately 39 μm in still air. © 1990 Elsevier Science Publishing Co., Inc.
引用
收藏
页码:459 / 464
页数:6
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