RANTES CHEMOKINE EXPRESSION IN CELL-MEDIATED TRANSPLANT REJECTION OF THE KIDNEY

被引：256

作者：

PATTISON, J ^{[1
]}

NELSON, PJ ^{[1
]}

HUIE, P ^{[1
]}

VONLEUTTICHAU, I ^{[1
]}

FARSHID, G ^{[1
]}

SIBLEY, RK ^{[1
]}

KRENSKY, AM ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,DEPT PATHOL,STANFORD,CA 94305

来源：

LANCET | 1994年 / 343卷 / 8891期

关键词：

D O I：

10.1016/S0140-6736(94)90992-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

RANTES (regulated upon activation, normal T cell expressed and secreted) is a chemotactic cytokine (a chemokine) for memory T lymphocytes, monocytes, and eosinophils. RANTES expression was studied in renal allograft biopsy specimens. Although RANTES was not expressed in samples,taken one hour after transplantation, or in native renal biopsy specimens from patients with cyclosporin nephrotoxicity, it was expressed during cell-mediated transplant rejection. RANTES mRNA was detected in infiltrating mononuclear cells and renal tubular epithelium, and RANTES protein was localised to mononuclear cells, tubular epithelium, and vascular endothelium. This suggests RANTES has a role in allograft rejection.

引用

页码：209 / 211

页数：3

共 10 条

[1] IMMUNOPATHOLOGY OF RENAL-ALLOGRAFT REJECTION ANALYZED WITH MONOCLONAL-ANTIBODIES TO MONONUCLEAR CELL MARKERS [J].