TIME COURSE OF IL-6 AND TNF-ALPHA RELEASE DURING ENDOTOXIN-INDUCED ENDOTOXIN TOLERANCE IN RATS

被引：48

作者：

FLOHE, S

HEINRICH, PC

SCHNEIDER, J

WENDEL, A

FLOHE, L

机构：

[1] GRUNENTHAL GMBH,CTR RES,W-5100 AACHEN,GERMANY

[2] UNIV KONSTANZ,W-7750 CONSTANCE 1,GERMANY

来源：

BIOCHEMICAL PHARMACOLOGY | 1991年 / 41卷 / 11期

关键词：

D O I：

10.1016/0006-2952(91)90161-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Development of endotoxin tolerance in rats induced by repeated application of low dosages of endotoxin is associated with repeatable IL-6 formation, reversible drop in white blood cells, pronounced consumption of platelets, gradual formation of alpha-2M as an example of acute phase proteins, and flattening TNF-alpha formation. In the status of full tolerance the TNF-alpha release is completely eliminated. Inhibition of TNF-alpha biosynthesis and induction of acute phase protein formation by IL-6 are discussed as possible factors in the development of endotoxin tolerance.

引用

页码：1607 / 1614

页数：8

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