NITRO RADICAL-ANION FORMATION FROM NIMODIPINE

被引：38

作者：

NUNEZVERGARA, LJ ^{[1
]}

BOLLO, S ^{[1
]}

ALVAREZ, AF ^{[1
]}

SQUELLA, JA ^{[1
]}

BLAZQUEZ, M ^{[1
]}

机构：

[1] UNIV CORDOBA,DEPT QUIM FIS,CORDOBA,SPAIN

来源：

JOURNAL OF ELECTROANALYTICAL CHEMISTRY | 1993年 / 345卷 / 1-2期

关键词：

D O I：

10.1016/0022-0728(93)80473-U

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Voltammetric studies of nimodipine using a mixed aqueous dimethylformamide (DMF) solvent have allowed us to generate the one-electron reduction product, the nitro radical anion RNO2-. The cyclic voltammetry technique has been employed to study the tendency of RNO2- to undergo further chemical reactions. This subsequent chemical reaction corresponds to a second-order process, a dismutation reaction which is initiated electrochemically. Data for rate constants and half-lives at pH 8.2 were determined in aqueous DMF media. A method which is able to generate selectively the RNO2- species electrochemically and to study its in-situ reactions is proposed.

引用

页码：121 / 133

页数：13

共 28 条

[1]

AMES J R, 1986, Journal of Free Radicals in Biology and Medicine, V2, P377, DOI 10.1016/S0748-5514(86)80040-X

[2] AN INTEGRATED CONCEPT OF AMEBICIDAL ACTION - ELECTRON-TRANSFER AND OXY RADICALS [J].

AMES, JR ;

HOLLSTEIN, U ;

GAGNEUX, AR ;

RYAN, MD ;

KOVACIC, P .

FREE RADICAL BIOLOGY AND MEDICINE, 1987, 3 (02) :85-96

[3]

BIAGLOW JE, 1977, MOL PHARMACOL, V13, P269

[4] BIOCHEMISTRY OF REDUCTION OF NITRO HETEROCYCLES [J].

BIAGLOW, JE ;

VARNES, ME ;

ROIZENTOWLE, L ;

CLARK, EP ;

EPP, ER ;

ASTOR, MB ;

HALL, EJ .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (01) :77-90

[5]

BONTEMPELLI G, 1989, ANN CHIM, V79, P138

[6] REDUCTION OF NITROIMIDAZOLES INVITRO AND DNA DAMAGE [J].

EDWARDS, DI .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (01) :53-58

[7]

KASTENING B, 1972, PROGR POLAROGRAPHY, V3, P261

[8]

LANDEY MS, 1989, DRUGS, V37, P669

[9]

LUND H, 1973, ORGANIC ELECTROCHEMI, pCH7

[10]

MAIRANOVSKII SG, 1971, PROGR ELECTROCHEMIST, P86

← 1 2 3 →