COMPARISON OF FLOW-INJECTION THERMOSPRAY MS/MS AND LC THERMOSPRAY MS/MS METHODS FOR DETERMINATION OF SULFONAMIDES IN MEAT AND BLOOD

被引:36
作者
KRISTIANSEN, GK [1 ]
BROOK, R [1 ]
BOJESEN, G [1 ]
机构
[1] ODENSE UNIV, DEPT CHEM, DK-5230 ODENSE, DENMARK
关键词
D O I
10.1021/ac00091a040
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Two quantitative analysis methods for measuring sulfonamides in spiked meat and blood samples are described. Both methods are based on thermospray tandem mass spectrometry. One method includes on-line liquid chromatographic separation before the tandem mass analysis and the other is based on now injection. The extraction procedure is a simple method where blood or minced meat is shaken with ethylacetate. The ethyl acetate phase is isolated and evaporated to dryness. The chromatographically separated sulfonamides are mass analyzed by detection of the characteristic fragment ion, m/z = 156, which all sulfonamides share. The mass analysis of the flow-injected samples is made by parent ion detection. The analysis method for the chromatographically separated compounds has slightly lower detection limits for the sulfonamides compared to the flow injection method. But the detection Limits for all compounds are well below the maximum residue limit of 50 ppb in meat. The flow injection method can analyze 40-60 extracts/h and show no contamination or sensitivity problems even after more than 1000 analyses of crude extracts. Both methods provide good sensitivity, some quantitative accuracy, and acceptable detection Limits.
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页码:3253 / 3258
页数:6
相关论文
共 22 条
[1]   HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY THERMOSPRAY MASS-SPECTROMETRY OF 10 SULFONAMIDE ANTIBIOTICS - ANALYSIS IN MILK AT THE PPB LEVEL [J].
ABIAN, J ;
CHURCHWELL, MI ;
KORFMACHER, WA .
JOURNAL OF CHROMATOGRAPHY, 1993, 629 (02) :267-276
[2]   THERMOSPRAY INTERFACE FOR LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY [J].
BLAKLEY, CR ;
VESTAL, ML .
ANALYTICAL CHEMISTRY, 1983, 55 (04) :750-754
[3]   DETERMINATION OF DRUGS IN BLOOD-SERUM BY MASS-SPECTROMETRY MASS-SPECTROMETRY [J].
BROTHERTON, HO ;
YOST, RA .
ANALYTICAL CHEMISTRY, 1983, 55 (03) :549-553
[4]  
CARIGNAN G, 1991, J ASSOC OFF ANA CHEM, V74, P479
[5]   RAPID QUALITATIVE IDENTIFICATION OF SULFONAMIDES BY MASS-SPECTROMETRY [J].
DAVIS, R ;
HURST, DT ;
TAYLOR, AR .
JOURNAL OF APPLIED CHEMISTRY AND BIOTECHNOLOGY, 1977, 27 (10) :543-548
[6]   MULTIRESIDUE ANALYSIS OF SULFONAMIDES USING LIQUID-CHROMATOGRAPHY WITH ATMOSPHERIC-PRESSURE CHEMICAL-IONIZATION MASS-SPECTROMETRY [J].
DOERGE, DR ;
BAJIC, S ;
LOWES, S .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1993, 7 (12) :1126-1130
[7]   SCREENING, CONFIRMATION, AND QUANTIFICATION OF SULFONAMIDE RESIDUES IN PIG-KIDNEY BY TANDEM MASS-SPECTROMETRY OF CRUDE EXTRACTS [J].
FINLAY, EMH ;
GAMES, DE ;
STARTIN, JR ;
GILBERT, J .
BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, 1986, 13 (11) :633-639
[8]   DETERMINATION OF SULFADIMETHOXINE IN THE LIVER AND KIDNEYS OF SWINE AND CATTLE BY GAS CHROMATOGRAPHY-CHEMICAL IONIZATION MASS-SPECTROMETRY AND STABLE ISOTOPE-DILUTION [J].
GARLAND, W ;
MIWA, B ;
WEISS, G ;
CHEN, G ;
SAPERSTEIN, R ;
MACDONALD, A .
ANALYTICAL CHEMISTRY, 1980, 52 (06) :842-846
[9]  
Haagsma N, 1987, Biomed Chromatogr, V2, P41, DOI 10.1002/bmc.1130020112
[10]  
HEITZMAN RJ, 1992, FINAL REPORT VET DRU