INVOLVEMENT OF FREE-RADICALS IN MPP(+) NEUROTOXICITY AGAINST RAT DOPAMINERGIC-NEURONS IN CULTURE

被引：49

作者：

AKANEYA, Y

TAKAHASHI, M

HATANAKA, H

机构：

[1] KINKI UNIV,SCH MED,DEPT NEUROL,OSAKA 589,JAPAN

[2] OSAKA UNIV,INST PROT RES,DIV PROT BIOSYNTH,OSAKA,JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 193卷 / 01期

关键词：

PARKINSONS DISEASE; ANTIOXIDANTS; GLUTAMATE RECEPTOR; N-METHYL-D-ASPARTIC ACID; CALCIUM; SURVIVAL; CELL DEATH;

D O I：

10.1016/0304-3940(95)11668-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To examine the mechanisms of the neurotoxicity of 1-methyl-4-phenylpyridinium (MPP(+)) against dopaminergic neurons, ventral mesencephalic cells from embryonic rats were cultured and exposed to MPP(+) with various antioxidants or glutamate receptor antagonists to investigate the participation of free radicals and glutamate, respectively. Such antioxidants as vitamin E, vitamin C, coenzyme Q(10), and catalase, but neither allopurinol nor superoxide dismutase, alleviated the MPP(+)-induced death of dopaminergic neurons, while glutamate receptor antagonists did not alter MPP(+) neurotoxicity. These findings suggest the participation of free radicals, particularly hydroxyl radicals rather than superoxides, in the process of dopaminergic neuronal death evoked by MPP(+).

引用

页码：53 / 56

页数：4

共 27 条

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