SPECTROFLUOROMETRIC DETERMINATION OF PARACETAMOL IN PHARMACEUTICALS AND BIOLOGICAL-FLUIDS

被引：106

作者：

VILCHEZ, JL ^{[1
]}

BLANC, R ^{[1
]}

AVIDAD, R ^{[1
]}

NAVALON, A ^{[1
]}

机构：

[1] UNIV GRANADA, DEPT QUIM ANALIT, E-18071 GRANADA, SPAIN

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1995年 / 13卷 / 09期

关键词：

SPECTROFLUOROMETRY; PARACETAMOL; PHARMACEUTICALS; BIOLOGICAL FLUIDS;

D O I：

10.1016/0731-7085(95)01537-U

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A spectrofluorimetric method for the determination of paracetamol is presented, based on the oxidation of the analyte to give the fluorophore 2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl. Sodium hypochlorite was used as an oxidizing reagent and the optimum pH was found to be 10.0 (sodium carbonate-boric acid buffer solution). The linear concentration range of application was 0.1-100.0 mu g ml(-1) of paracetamol, the detection limit 0.01 mu g ml(-1) and the relative standard deviation 1.2%. The method has been satisfactorily applied to the determination of paracetamol in pharmaceutical formulations and biological fluids.

引用

页码：1119 / 1125

页数：7

共 27 条

[1] SPECTROFLUORIMETRIC DETERMINATION OF PHARMACEUTICAL COMPOUNDS WITH THE CERIUM(IV)-CERIUM(III) SYSTEM [J].

AMANN, G ;

GUBITZ, G ;

FREI, RW ;

SANTI, W .

ANALYTICA CHIMICA ACTA, 1980, 116 (01) :119-125

[2]

[Anonymous], 1980, ANAL CHEM, V52, P2242

[3] QUANTITATIVE INSITU THIN-LAYER CHROMATOGRAPHY OF QUINIDINE AND SALICYLIC-ACID IN CAPILLARY BLOOD [J].

CHRISTIANSEN, J .

JOURNAL OF CHROMATOGRAPHY, 1976, 123 (01) :57-63

[4]

DERTINGER G, 1972, PHARM IND, V34, P114

[5] SPECTROPHOTOMETRIC DETERMINATION OF ACETAMINOPHEN, OXYPHENBUTAZONE AND SALICYLAMIDE BY NITRATION AND SUBSEQUENT COMPLEXATION REACTIONS [J].

ELKHEIR, AA ;

BELAL, S ;

ELSADEK, M ;

ELSHANWANI, A .

ANALYST, 1986, 111 (03) :319-321

[6]

ELOBEID A, 1985, ANAL PROFILES DRUG S, P551

[7]

FAIRBROTHER JE, 1972, ANAL PROFILES DRUG S, P2

[8]

FLOREY K, 1974, ANAL PROFILES DRUG S, V3, P79

[9]

GARCIA RM, 1990, QUIM ANAL, V9, P189

[10]

HABERLI E, 1959, Pharm Acta Helv, V34, P65

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