SELECTION OF A DERIVATIVE OF THE ANTIVIRAL AGENT 9-[(1,3-DIHYDROXY-2-PROPOXY)-METHYL]GUANINE (DHPG) WITH IMPROVED ORAL ABSORPTION

被引：19

作者：

BENJAMIN, EJ

FIRESTONE, BA

BERGSTROM, R

FASS, M

MASSEY, I

TSINA, I

LIN, YYT

机构：

[1] SYNTEX RES CORP,INST PHARMACEUT SCI,PALO ALTO,CA 94304

[2] SYNTEX RES CORP,INST PHARMACOL & METAB,PALO ALTO,CA 94304

来源：

PHARMACEUTICAL RESEARCH | 1987年 / 4卷 / 02期

关键词：

D O I：

10.1023/A:1016462801968

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

收藏

页码：120 / 125

页数：6

相关论文

共 26 条

[1] PRODRUGS OF 9-(BETA-D-ARABINOFURANOSYL)ADENINE .2. SYNTHESIS AND EVALUATION OF A NUMBER OF 2',3'-DI-O-ACYL DERIVATIVES AND 3',5'-DI-O-ACYL DERIVATIVES
BAKER, DC
HASKELL, TH
PUTT, SR
SLOAN, BJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (03) : 273 - 279
[2] PRODRUGS OF 9-BETA-D-ARABINOFURANOSYLADENINE .1. SYNTHESIS AND EVALUATION OF SOME 5'-(O-ACYL) DERIVATIVES
BAKER, DC
HASKELL, TH
PUTT, SR
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (12) : 1218 - 1221
[3] A DUAL-COLUMN HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF DHPG (9-[(1,3-DIHYDROXY-2-PROPOXY)METHYL]GUANINE) AND ITS MONO AND DIESTERS IN BIOLOGICAL SAMPLES
BENJAMIN, EJ
FIRESTONE, BA
SCHNEIDER, JA
[J]. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1985, 23 (04) : 168 - 170
[4] PREPARATION AND INVITRO EVALUATION OF SALTS OF AN ANTIHYPERTENSIVE AGENT TO OBTAIN SLOW RELEASE
BENJAMIN, EJ
LIN, LH
[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1985, 11 (04) : 771 - 790
[5] BURR A, 1985, INT J PHARM, V24, P43
[6] SYNTHESIS AND ANTIVIRAL ACTIVITY OF WATER-SOLUBLE ESTERS OF ACYCLOVIR [9-[(2-HYDROXYETHOXY)METHYL]GUANINE]
COLLA, L
DECLERCQ, E
BUSSON, R
VANDERHAEGHE, H
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (04) : 602 - 604
[7] DIXON W, 1964, ENZYMES
[8] HIGUCHI T, 1982, PHARMACOKINET, P67
[9] HIGUCHI T, 1975, ACS S SERIES, V14
[10] HO NFH, 1977, DESIGN BIOPHARMACEUT, pCH8