DESIGN OF INHIBITORS FROM THE 3-DIMENSIONAL STRUCTURE OF ALCOHOL-DEHYDROGENASE - CHEMICAL SYNTHESIS AND ENZYMATIC-PROPERTIES

被引：32

作者：

FREUDENREICH, C ^{[1
]}

SAMAMA, JP ^{[1
]}

BIELLMANN, JF ^{[1
]}

机构：

[1] UNIV STRASBOURG 1,INST CHIM,CNRS,CHIM ORGAN BIOL LAB,F-67008 STRASBOURG,FRANCE

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1984年 / 106卷 / 11期

关键词：

D O I：

10.1021/ja00323a048

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：3344 / 3353

页数：10

共 35 条

[1] COMPOUNDS DESIGNED TO FIT A SITE OF KNOWN STRUCTURE IN HUMAN HEMOGLOBIN [J].

BEDDELL, CR ;

GOODFORD, PJ ;

NORRINGTON, FE ;

WILKINSON, S ;

WOOTTON, R .

BRITISH JOURNAL OF PHARMACOLOGY, 1976, 57 (02) :201-209

[2] MECHANISTIC STUDIES ON EQUINE LIVER ALCOHOL DEHYDROGENASE .1. STOICHIOMETRY RELATIONSHIP OF COENZYME BINDING SITES TO CATALYTIC SITES ACTIVE IN REDUCTION OF AROMATIC ALDEHYDES IN TRANSIENT STATE [J].

BERNHARD, SA ;

DUNN, MF ;

LUISI, PL ;

SCHACK, P .

BIOCHEMISTRY, 1970, 9 (01) :185-&

[3] OXIDATION OF OMEGA-HYDROXYLATED FATTY-ACIDS AND STEROIDS BY ALCOHOL-DEHYDROGENASE [J].

BJORKHEM, I ;

JORNVALL, H ;

ZEPPEZAUER, E .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1973, 52 (02) :413-420

[4] OXIDATION OF OMEGA-HYDROXYLATED FATTY-ACIDS AND STEROIDS BY SS-ISOENZYME OF LIVER ALCOHOL-DEHYDROGENASE [J].

BJORKHEM, I ;

JORNVALL, H ;

AKESON, A .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 57 (03) :870-875

[5] COMPUTER-GRAPHICS IN DRUG DESIGN - MOLECULAR MODELING OF THYROID-HORMONE PRE-ALBUMIN INTERACTIONS [J].

BLANEY, JM ;

JORGENSEN, EC ;

CONNOLLY, ML ;

FERRIN, TE ;

LANGRIDGE, R ;

OATLEY, SJ ;

BURRIDGE, JM ;

BLAKE, CCF .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (07) :785-790

[6] CRYSTAL-STRUCTURE DETERMINATIONS OF CO-ENZYME ANALOG AND SUBSTRATE COMPLEXES OF LIVER ALCOHOL-DEHYDROGENASE - BINDING OF 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE-DINUCLEOTIDE AND TRANS-4-(N,N-DIMETHYLAMINO)CINNAMALDEHYDE TO THE ENZYME [J].

CEDERGRENZEPPEZAUER, E ;

SAMAMA, JP ;

EKLUND, H .

BIOCHEMISTRY, 1982, 21 (20) :4895-4908

[7] AMBIVALENT ACTIVE-SITE-DIRECTED INACTIVATORS OF LIVER ALCOHOL-DEHYDROGENASE [J].

CHEN, WS ;

PLAPP, BV .

BIOCHEMISTRY, 1978, 17 (23) :4916-4922

[8] METABOLIC RESISTANCE - THE PROTECTION OF ENZYMES AGAINST DRUGS WHICH ARE TIGHT-BINDING INHIBITORS BY THE ACCUMULATION OF SUBSTRATE [J].

CHRISTOPHERSON, RI ;

DUGGLEBY, RG .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1983, 134 (02) :331-335

[9] ROLES OF ZINC ION AND REDUCED COENZYME IN HORSE LIVER ALCOHOL-DEHYDROGENASE CATALYSIS - MECHANISM OF ALDEHYDE ACTIVATION [J].

DUNN, MF ;

BIELLMANN, JF ;

BRANLANT, G .

BIOCHEMISTRY, 1975, 14 (14) :3176-3182

[10] ROLES OF ZINC ION AND REDUCED COENZYME IN FORMATION OF A TRANSIENT CHEMICAL INTERMEDIATE DURING EQUINE LIVER ALCOHOL-DEHYDROGENASE CATALYZED REDUCTION OF AN AROMATIC ALDEHYDE [J].

DUNN, MF ;

HUTCHISON, JS .

BIOCHEMISTRY, 1973, 12 (24) :4882-4892

← 1 2 3 4 →