ENDOTHELIN AND ATRIAL-NATRIURETIC-PEPTIDE AFTER EXERCISE PERFORMED UNTIL EXHAUSTION IN THE RAT

被引：12

作者：

ALLEVARD, AM ^{[1
]}

GAUQUELIN, G ^{[1
]}

GHARIB, C ^{[1
]}

机构：

[1] FAC MED GRANGE BLANCHE,PHYSIOL ENVIRONN LAB,8 AVE ROCKEFELLER,F-69373 LYONS 08,FRANCE

来源：

LIFE SCIENCES | 1991年 / 49卷 / 24期

关键词：

D O I：

10.1016/0024-3205(91)90481-P

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Endothelin-1(ET) is a recently discovered endothelium-derived vasoconstrictor peptide. Plasma concentrations of immunoreactive (IR-) endothelin were investigated in rats by radioimmunoassay after extraction of endothelin on Sep-Pak Cartridges. In control rats, a mean concentration of 1.03 +/- 0.2 pg/ml was found. After exercise performed until semi-exhaustion or exhaustion, the mean plasma concentration of IR-endothelin decreased. An increase of Atrial Natriuretic Peptide plasma was observed immediately after exercise. There was a negative correlation between Endothelin and Atrial Natriuretic Peptide (r = -0.73, p < 0.001). This is the first time that this increase following exercise is shown in normotensive rat. The mechanisms of the decrease of Endothelin are unclear. One hypothesis could be that the decrease in Endothelin is related to its rapid removal by the different tissues, specially the lungs.

引用

页码：1803 / 1808

页数：6

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