SERONEGATIVITY FOR TYPE-1 ANTINEURONAL NUCLEAR ANTIBODIES (ANTI-HU) IN SUBACUTE SENSORY NEURONOPATHY PATIENTS WITHOUT CANCER

被引：28

作者：

CHALK, CH

LENNON, VA

STEVENS, JC

WINDEBANK, AJ

机构：

[1] MAYO CLIN & MAYO FDN, DEPT NEUROL, 1501 GUGGENHEIM BLDG, 200 1ST ST SW, ROCHESTER, MN 55905 USA

[2] MAYO CLIN, SCOTTSDALE, AZ USA

来源：

NEUROLOGY | 1993年 / 43卷 / 11期

关键词：

D O I：

10.1212/WNL.43.11.2209

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We followed 21 patients with sensory neuronopathy without evidence of cancer for up to 23 years. All were seronegative for type 1 antineuronal nuclear antibodies (ANNA-1, also called ''anti-Hu''). We additionally studied 67 seropositive patients with sensory neuronopathy or a related neurologic syndrome. Ninety-one percent of the seropositive patients had a small-cell lung carcinoma. One, with a normal chest x-ray, had been followed for 7 years for sensory neuronopathy of indeterminate cause before serologic testing for ANNA-1 led to the discovery of the tumor by CT. We conclude that ANNA-1 seropositivity in a patient with sensory neuronopathy is strong evidence for an underlying small-cell lung cancer.

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页码：2209 / 2211

页数：3

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